The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide.
The airway response of horses with recurrent airway obstruction (heaves) to aerosol administration of ipratropium bromide.
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反复发生气道阻塞（呕吐）的马对异丙托溴铵气雾给药的气道反应。
DOI：
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发表时间：
1993
影响因子：
2.2
通讯作者：
L. Goossens
中科院分区：
文献类型：
--
作者：
N. E. Robinson;F. Derksen;C. Berney;L. Goossens;L. Goossens
在 8 匹患有反复性气道阻塞（气喘）的马中测定了抗胆碱能药物异丙托溴铵气雾给药的气道反应。通过在稳定前和稳定期间测量肺功能来证实气道阻塞的可逆性；并确定对阿托品给药（静脉注射 0.02 mg/kg bwt）的反应。使用威廉姆斯方设计实验确定对异丙托溴铵的剂量反应，其中通过雾化将25、50或75微克异丙托溴胺/ml(4ml/100kg bwt)或相同体积的媒介物施用至每匹马。在雾化前以及雾化后 1 小时和 4 小时测量肺功能。媒介物对肺功能没有影响。异丙托溴铵可降低潮式呼吸期间胸膜压的最大变化 (delta Pplmax) 和肺阻力 (RL)，并增加动态顺应性 (Cdyn)。在 1 小时测量期间，对 RL 和 Cdyn 的影响呈剂量依赖性。一项单独的实验表明，异丙托铵的作用持续时间在 4 至 6 小时之间。
The airway response to aerosol administration of the anticholinergic agent ipratropium bromide was determined in 8 horses with recurrent airway obstruction (heaves). The reversibility of airway obstruction was confirmed by measuring lung function before and during stabling; and by determining the response to atropine administration (0.02 mg/kg bwt intravenously). The dose-response to ipratropium bromide was determined using a Williams square design experiment in which 25, 50 or 75 micrograms ipratropium bromide/ml (4 ml/100 kg bwt) or the same volume of vehicle was administered to each horse by nebulisation. Lung function was measured before and 1 and 4 h after nebulisation. Vehicle had no effect on lung function. Ipratropium decreased the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increased dynamic compliance (Cdyn). At the 1 h measurement period, the effect on RL and Cdyn was dose-dependent. A separate experiment demonstrated that the duration of action of ipratropium was between 4 and 6 h.
反复气道阻塞的马远端气道的体外反应。
影响因子：
1
作者：
LeBlanc,PH;Broadstone,RV;Derksen,FJ;Robinson,NE
通讯作者：
Robinson,NE
肠胃外与吸入阿托品：最大呼气流量的密度依赖性。
DOI：
10.1152/jappl.1982.53.2.392
发表时间：
1982
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
--
作者：
Weiss,JW;McFaddenJr,ER;IngramJr,RH
通讯作者：
IngramJr,RH