Live imaging of the pulmonary immune environment.
Live imaging of the pulmonary immune environment.
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DOI：
10.1016/j.cellimm.2018.09.007
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发表时间：
2020-04
影响因子：
4.3
通讯作者：
Headley MB
中科院分区：
文献类型：
--
作者：
Looney MR;Headley MB
肺是一个独特的免疫环境。肺的主要功能是通过促进氧气进入血液和二氧化碳排出血液来实现气体交换。然而，作为这一过程的直接副产品，肺也不断暴露于空气本身的颗粒，过敏原和病原体。因此，肺部免疫系统在静止和炎症之间存在良好的平衡，偏离这种平衡可能导致呼吸功能衰竭。有丰富的历史存在试图定义肺免疫的关键特征，最近的进展，在活体显微镜已经使细胞间免疫动力学的可视化在稳态和各种疾病的条件。在这篇综述中，我们将总结各种方法，活体肺成像，以及它的应用如何提高了我们对正常肺功能的理解，以及疾病状态，如肺转移，哮喘和肺损伤。
The lung represents a unique immune environment. The primary function of the lung is to enable gas exchange by facilitating the transfer of oxygen into and carbon dioxide out of the blood. However, as a direct byproduct of this process the lung is also constantly exposed to particles, allergens, and pathogens alongside air itself. Due to this, the pulmonary immune system exists in a fine balance between quiescence and inflammation, deviations from which can lead to a failure in respiratory function. A rich history exists attempting to define the critical features of lung immunity, and most recently advances in intravital microscopy have enabled the visualization of intercellular immune dynamics in both steady-state and a variety of disease conditions. In this review, we will summarize a variety of approaches to intravital lung imaging as well as how its application has advanced our understanding of normal lung function as well as disease states such as pulmonary metastasis, asthma, and lung injury.
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影响因子：
64.8
作者：
Headley MB;Bins A;Nip A;Roberts EW;Looney MR;Gerard A;Krummel MF
通讯作者：
Krummel MF
DOI：
10.1084/jem.20160800
发表时间：
2016-10-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chong SZ;Evrard M;Devi S;Chen J;Lim JY;See P;Zhang Y;Adrover JM;Lee B;Tan L;Li JL;Liong KH;Phua C;Balachander A;Boey A;Liebl D;Tan SM;Chan JK;Balabanian K;Harris JE;Bianchini M;Weber C;Duchene J;Lum J;Poidinger M;Chen Q;Rénia L;Wang CI;Larbi A;Randolph GJ;Weninger W;Looney MR;Krummel MF;Biswas SK;Ginhoux F;Hidalgo A;Bachelerie F;Ng LG
通讯作者：
Ng LG
影响因子：
4.6
作者：
Li JT;Wang H;Li W;Wang LF;Hou LC;Mu JL;Liu X;Chen HJ;Xie KL;Li NL;Gao CF
通讯作者：
Gao CF
影响因子：
10.7
作者：
Burburan, S. M.;Silva, J. D.;Rocco, P. R. M.
通讯作者：
Rocco, P. R. M.
影响因子：
1.2
作者：
Kandasamy, Kathirvel;Parthasarathi, Kaushik
通讯作者：
Parthasarathi, Kaushik