COPD association and repeatability of blood biomarkers in the ECLIPSE cohort.
COPD association and repeatability of blood biomarkers in the ECLIPSE cohort.
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DOI：
10.1186/1465-9921-12-146
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发表时间：
2011-11-04
影响因子：
5.8
通讯作者：
Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators
中科院分区：
文献类型：
--
作者：
Dickens JA;Miller BE;Edwards LD;Silverman EK;Lomas DA;Tal-Singer R;Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) study investigators
需要生物标志物来更好地监测患有COPD的个体并帮助开发治疗干预。在COPD纵向评价以确定替代终点（ECLIPSE）队列的一个亚组中评估了一组推定的血液生物标志物。在201例COPD受试者、37例肺功能正常的既往吸烟者对照和37例选自ECLIPSE队列的健康非吸烟者中评估了34种血液生物标志物。使用基线和3个月样本评估生物标志物重复性。使用方差分析进行组间比较，通过Bland-Altman图评估重复性，并使用斯皮尔曼相关系数评估生物标志物和临床特征之间的相关性。15种生物标志物在COPD患者中与既往或非吸烟者对照组相比存在显著差异。包括肿瘤坏死因子-α和干扰素-γ在内的一些生物标志物仅在少数受试者中可测量，而其他生物标志物（如C反应蛋白）在3个月的复制期内显示出广泛的变异性。纤维蛋白原是最可重复的生物标志物，与COPD受试者的6分钟步行距离、加重率、BODE指数和MRC呼吸困难评分呈弱相关性。33%（66/201）的COPD受试者在3个月研究期间报告了至少1次急性加重，18%（36/201）的受试者在3个月访视后30天内报告了急性加重。与未加重或加重已消退的受试者相比，3个月访视后30天内发生加重的COPD受试者的CRP、纤维蛋白原、白细胞介素-6和表面活性蛋白-D显著升高。只有少数评估的生物标志物可用于诊断或管理COPD，其中诊断是基于气流阻塞（GOLD）。对更有希望的生物标志物的进一步分析可能揭示其在患者亚群中的效用。特别是纤维蛋白原已成为该队列中潜在有用的生物标志物，需要进一步研究。SCO 104960，clinicaltrials.gov标识符NCT 00292552
There is a need for biomarkers to better characterise individuals with COPD and to aid with the development of therapeutic interventions. A panel of putative blood biomarkers was assessed in a subgroup of the Evaluation of COPD Longitudinally to Identify Surrogate Endpoints (ECLIPSE) cohort. Thirty-four blood biomarkers were assessed in 201 subjects with COPD, 37 ex-smoker controls with normal lung function and 37 healthy non-smokers selected from the ECLIPSE cohort. Biomarker repeatability was assessed using baseline and 3-month samples. Intergroup comparisons were made using analysis of variance, repeatability was assessed through Bland-Altman plots, and correlations between biomarkers and clinical characteristics were assessed using Spearman correlation coefficients. Fifteen biomarkers were significantly different in individuals with COPD when compared to former or non-smoker controls. Some biomarkers, including tumor necrosis factor-α and interferon-γ, were measurable in only a minority of subjects whilst others such as C-reactive protein showed wide variability over the 3-month replication period. Fibrinogen was the most repeatable biomarker and exhibited a weak correlation with 6-minute walk distance, exacerbation rate, BODE index and MRC dyspnoea score in COPD subjects. 33% (66/201) of the COPD subjects reported at least 1 exacerbation over the 3 month study with 18% (36/201) reporting the exacerbation within 30 days of the 3-month visit. CRP, fibrinogen interleukin-6 and surfactant protein-D were significantly elevated in those COPD subjects with exacerbations within 30 days of the 3-month visit compared with those individuals that did not exacerbate or whose exacerbations had resolved. Only a few of the biomarkers assessed may be useful in diagnosis or management of COPD where the diagnosis is based on airflow obstruction (GOLD). Further analysis of more promising biomarkers may reveal utility in subsets of patients. Fibrinogen in particular has emerged as a potentially useful biomarker from this cohort and requires further investigation. SCO104960, clinicaltrials.gov identifier NCT00292552
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影响因子：
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