Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.
Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.
复制标题
非洲爪蟾的中面部裂：视黄酸信号传导和同源盒基因的作用。
DOI：
10.1016/j.ydbio.2012.02.033
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发表时间：
2012
影响因子：
2.7
通讯作者：
A. Dickinson
中科院分区：
文献类型：
--
作者：
Allyson E. Kennedy;A. Dickinson
The upper lip and primary palate form an essential separation between the brain, nasal structures and the oral cavity. Surprisingly little is known about the development of these structures, despite the fact that abnormalities can result in various forms of orofacial clefts. We have uncovered that retinoic acid is a critical regulator of upper lip and primary palate development in Xenopus laevis. Retinoic acid synthesis enzyme, RALDH2, and retinoic acid receptor gamma (RARγ) are expressed in complementary and partially overlapping regions of the orofacial prominences that fate mapping revealed contribute to the upper lip and primary palate. Decreased RALDH2 and RARγ result in a median cleft in the upper lip and primary palate. To further understand how retinoic acid regulates upper lip and palate morphogenesis we searched for genes downregulated in response to RARγ inhibition in orofacial tissue, and uncovered homeobox genes lhx8 and msx2. These genes are both expressed in overlapping domains with RARγ, and together their loss of function also results in a median cleft in the upper lip and primary palate. Inhibition of RARγ and decreased Lhx8/Msx2 function result in decreased cell proliferation and failure of dorsal anterior cartilages to form. These results suggest a model whereby retinoic acid signaling regulates Lhx8 and Msx2, which together direct the tissue growth and differentiation necessary for the upper lip and primary palate morphogenesis. This work has the potential to better understand the complex nature of the upper lip and primary palate development which will lead to important insights into the etiology of human orofacial clefts.
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Msx1 和 Msx2 在神经嵴中具有共同的基本功能，但在非洲爪蟾的表皮和轴形成中可能是可有可无的。
DOI：
10.1387/ijdb.052115dk
发表时间：
2006
期刊：
The International journal of developmental biology
影响因子：
--
作者：
Khadka,Deepak;Luo,Ting;Sargent,ThomasD
通讯作者：
Sargent,ThomasD
影响因子：
4.6
作者：
C. Mendelsohn;D. Lohnes;D. Décimo;T. Lufkin;M. Lemeur;P. Chambon;M. Mark
通讯作者：
C. Mendelsohn;D. Lohnes;D. Décimo;T. Lufkin;M. Lemeur;P. Chambon;M. Mark
影响因子：
7.3
作者：
Liu B;Rooker SM;Helms JA
通讯作者：
Helms JA
v-erbA 和柠檬醛分别降低全反式视黄酸和视黄醇在爪蟾胚胎发生中的致畸作用。
DOI：
10.1242/dev.119.3.785
发表时间：
1993
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Schuh,TJ;Hall,BL;Kraft,JC;Privalsky,ML;Kimelman,D
通讯作者：
Kimelman,D
影响因子：
4.6
作者：
G. Hu;Hansol Lee;Sandy M. Price;M. Shen;C. Abate-Shen
通讯作者：
G. Hu;Hansol Lee;Sandy M. Price;M. Shen;C. Abate-Shen