Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.
Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.
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新生儿中骨髓源性抑制细胞的短暂存在对于控制炎症至关重要。
DOI：
10.1038/nm.4467
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发表时间：
2018-03
期刊：
影响因子：
82.9
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
He YM;Li X;Perego M;Nefedova Y;Kossenkov AV;Jensen EA;Kagan V;Liu YF;Fu SY;Ye QJ;Zhou YH;Wei L;Gabrilovich DI;Zhou J
髓源性抑制细胞（myeloid -derived suppressor cells， MDSC）是一种病理活化且相对不成熟的髓系细胞，参与许多病理状况的免疫调节。MDSC在表型和形态学上类似于中性粒细胞（PMN-MDSC）和单核细胞（M-MDSC）。然而，它们具有强大的抑制活性，独特的基因表达谱和生化特性。在稳态生理条件下没有或很少观察到MDSC。因此，直到最近，MDSC的积累被认为是病理过程或妊娠的结果。在这里，我们报告了具有有效抑制T细胞能力的MDSC在小鼠和人类生命的最初几周内存在。MDSC抑制活性由乳铁蛋白触发，并由一氧化氮、PGE2和S100A9/A8蛋白介导。新生MDSC的转录组与肿瘤MDSC相似，但抗菌基因网络的表达明显上调，具有较强的抗菌活性。MDSC在新生小鼠实验性坏死性小肠结肠炎（NEC）的控制中起关键作用。体重极低的婴儿更易发生NEC，其MDSC水平和抑制活性低于体重正常的婴儿。因此，短暂存在的MDSC可能对新生儿炎症的调节至关重要。
Myeloid-derived suppressor cells (MDSC) are pathologically activated and relatively immature myeloid cells, which are implicated in the immune regulation of many pathologic conditions. Phenotypically and morphologically MDSC are similar to neutrophils (PMN-MDSC) and monocytes (M-MDSC). However, they have potent suppressive activity, a distinct gene expression profile, and biochemical characteristics. None or very few MDSC are observed in steady state physiological conditions. Therefore, until recently, accumulation of MDSC was considered as a consequence of pathological process or pregnancy. Here, we report that MDSC with a potent ability to suppress T cells are present during the first weeks of life in mice and humans. MDSC suppressive activity was triggered by lactoferrin and mediated by nitric oxide, PGE2, and S100A9/A8 proteins. Newborn MDSC had a transcriptome similar to that of tumor MDSC, but with a strong up-regulation of an antimicrobial gene network and had potent antibacterial activity. MDSC played a critical role in control of experimental necrotizing enterocolitis (NEC) in newborn mice. MDSC in infants with very low-weight, which are prone to the development of NEC, had lower MDSC levels and suppressive activity than infants with normal weight. Thus, the transitory presence of MDSC may be critical for regulation of inflammation in newborns.
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影响因子：
30.3
作者：
Kubinak JL;Petersen C;Stephens WZ;Soto R;Bake E;O'Connell RM;Round JL
通讯作者：
Round JL
DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
影响因子：
10.1
作者：
Gabrilovich DI
通讯作者：
Gabrilovich DI
影响因子：
5.8
作者：
James, Britnie R.;Anderson, Kristin G.;Brincks, Erik L.;Kucaba, Tamara A.;Norian, Lyse A.;Masopust, David;Griffith, Thomas S.
通讯作者：
Griffith, Thomas S.
影响因子：
3.4
作者：
Denning TL;Bhatia AM;Kane AF;Patel RM;Denning PW
通讯作者：
Denning PW