Forebrain projections to brainstem nuclei involved in the control of mandibular movements in rats.
Forebrain projections to brainstem nuclei involved in the control of mandibular movements in rats.
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前脑对脑干核的投射参与控制大鼠下颌运动。
DOI：
10.1111/j.1600-0722.2009.00686.x
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发表时间：
2009
影响因子：
1.9
通讯作者：
C. Elias
中科院分区：
文献类型：
--
作者：
M. B. Mascaro;F. Prosdocimi;J. Bittencourt;C. Elias
下颌运动通过触发三叉神经运动神经元而发生。口面部肌肉的异常运动是口面部运动障碍的特征，例如夜间磨牙症（睡眠期间牙列紧咬或研磨）。以前的研究表明，自主神经的变化发生在磨牙症发作。虽然我们知道情绪反应会增加下颌运动，但连接前脑边缘核和三叉神经运动核的大脑通路仍然不清楚。在这里，我们表明，神经元在下丘脑外侧区，杏仁核的中央核，并在丘脑旁核，项目的三叉神经运动核或网状区域周围的运动核（区域h）和中脑三叉神经核。我们观察到下丘脑外侧区投射到三叉神经运动核的神经元食欲素的共同表达。在杏仁核中央核，投射到三叉神经运动核的神经元受促肾上腺皮质激素释放因子免疫反应纤维支配。我们还观察到，中脑三叉神经核接受来自食欲素和促肾上腺皮质激素释放因子免疫反应纤维的密集神经支配。因此，与自主控制和应激反应相关的前脑核团可能影响三叉神经运动神经元的活动，从而在夜间磨牙症的病理生理学中发挥作用。
Mandibular movements occur through the triggering of trigeminal motoneurons. Aberrant movements by orofacial muscles are characteristic of orofacial motor disorders, such as nocturnal bruxism (clenching or grinding of the dentition during sleep). Previous studies have suggested that autonomic changes occur during bruxism episodes. Although it is known that emotional responses increase jaw movement, the brain pathways linking forebrain limbic nuclei and the trigeminal motor nucleus remain unclear. Here we show that neurons in the lateral hypothalamic area, in the central nucleus of the amygdala, and in the parasubthalamic nucleus, project to the trigeminal motor nucleus or to reticular regions around the motor nucleus (Regio h) and in the mesencephalic trigeminal nucleus. We observed orexin co-expression in neurons projecting from the lateral hypothalamic area to the trigeminal motor nucleus. In the central nucleus of the amygdala, neurons projecting to the trigeminal motor nucleus are innervated by corticotrophin-releasing factor immunoreactive fibers. We also observed that the mesencephalic trigeminal nucleus receives dense innervation from orexin and corticotrophin-releasing factor immunoreactive fibers. Therefore, forebrain nuclei related to autonomic control and stress responses might influence the activity of trigeminal motor neurons and consequently play a role in the physiopathology of nocturnal bruxism.
DOI：
10.1073/pnas.91.19.8777
发表时间：
1994-09-13
影响因子：
11.1
作者：
POTTER, E;SUTTON, S;VALE, W
通讯作者：
VALE, W