Reexamining assumptions about miRNA-guided gene silencing.
Reexamining assumptions about miRNA-guided gene silencing.
复制标题
DOI：
10.1093/nar/gkab1256
复制
发表时间：
2022-01-25
影响因子：
14.9
通讯作者：
Corey DR
中科院分区：
文献类型：
--
作者：
Kilikevicius A;Meister G;Corey DR
微小RNA（miRNAs）是内源性表达的短RNA，具有调节任何RNA表达的潜力。这种潜力导致每年发表数千篇论文，将miRNAs与许多不同的基因和人类疾病联系起来。相比之下，相对较少的论文出现，研究miRNA使用的分子机制。对miRNAs作用机制的严格理解与miRNAs所报道的作用的异常多样性之间存在脱节。这种脱节的后果包括对人类miRNAs基础科学假设的混淆以及靶向miRNAs治疗方法的缓慢发展。在这里，我们提出了一个概述的研究miRNAs及其对基因表达的影响。我们对miRNAs的理解的进展将有助于对miRNAs机制的更多关注，以及寻求将特定miRNAs的表达与生物表型联系起来的研究人员的更高证据负担。
MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to regulate the expression of any RNA. This potential has led to the publication of several thousand papers each year connecting miRNAs to many different genes and human diseases. By contrast, relatively few papers appear that investigate the molecular mechanism used by miRNAs. There is a disconnect between rigorous understanding of mechanism and the extraordinary diversity of reported roles for miRNAs. Consequences of this disconnect include confusion about the assumptions underlying the basic science of human miRNAs and slow development of therapeutics that target miRNAs. Here, we present an overview of investigations into miRNAs and their impact on gene expression. Progress in our understanding of miRNAs would be aided by a greater focus on the mechanism of miRNAs and a higher burden of evidence on researchers who seek to link expression of a particular miRNA to a biological phenotype.
登录
查看更多内容
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
14.9
作者：
Abugessaisa I;Ramilowski JA;Lizio M;Severin J;Hasegawa A;Harshbarger J;Kondo A;Noguchi S;Yip CW;Ooi JLC;Tagami M;Hori F;Agrawal S;Hon CC;Cardon M;Ikeda S;Ono H;Bono H;Kato M;Hashimoto K;Bonetti A;Kato M;Kobayashi N;Shin J;de Hoon M;Hayashizaki Y;Carninci P;Kawaji H;Kasukawa T
通讯作者：
Kasukawa T
影响因子：
16
作者：
Bosson, Andrew D.;Zamudio, Jesse R.;Sharp, Phillip A.
通讯作者：
Sharp, Phillip A.
影响因子：
5.3
作者：
Baillat, David;Shiekhattar, Ramin
通讯作者：
Shiekhattar, Ramin
影响因子：
4
作者：
Aartsma-Rus, Annemieke;Corey, David R.
通讯作者：
Corey, David R.