FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs.
FANTOM enters 20th year: expansion of transcriptomic atlases and functional annotation of non-coding RNAs.
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DOI：
10.1093/nar/gkaa1054
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发表时间：
2021-01-08
影响因子：
14.9
通讯作者：
Kasukawa T
中科院分区：
文献类型：
--
作者：
Abugessaisa I;Ramilowski JA;Lizio M;Severin J;Hasegawa A;Harshbarger J;Kondo A;Noguchi S;Yip CW;Ooi JLC;Tagami M;Hori F;Agrawal S;Hon CC;Cardon M;Ikeda S;Ono H;Bono H;Kato M;Hashimoto K;Bonetti A;Kato M;Kobayashi N;Shin J;de Hoon M;Hayashizaki Y;Carninci P;Kawaji H;Kasukawa T
在过去的20年里，哺乳动物基因组功能注释（FANTOM）联盟一直在为了解哺乳动物基因组的转录组和转录调控提供广泛的资源。为了与研究界分享这些资源，FANTOM的网络界面和数据库正定期更新、增强和扩展新的数据类型。近年来，FANTOM联盟的工作主要集中在创建新的非编码RNA数据集和资源。现有的FANTOM5人和小鼠miRNA图谱补充了大鼠、狗和鸡的数据集。第六版（最新版）FANTOM项目启动，以评估人类长链非编码rna （lncRNAs）的功能。从创建到2020年，FANTOM6为研究界贡献了一个大型数据集，该数据集是由人类皮肤成纤维细胞中285个lncrna的敲除生成的；随后是广泛的表达谱和细胞表型。FANTOM资源的其他更新包括用最新的参考基因组组合重新处理人类、小鼠和鸡的miRNA和启动子图谱。为了方便使用和使用上述资源，我们进一步加强了FANTOM的数据查看器和网页界面。更新后的FANTOM web资源可在https://fantom.gsc.riken.jp/公开获取。
The Functional ANnoTation Of the Mammalian genome (FANTOM) Consortium has continued to provide extensive resources in the pursuit of understanding the transcriptome, and transcriptional regulation, of mammalian genomes for the last 20 years. To share these resources with the research community, the FANTOM web-interfaces and databases are being regularly updated, enhanced and expanded with new data types. In recent years, the FANTOM Consortium's efforts have been mainly focused on creating new non-coding RNA datasets and resources. The existing FANTOM5 human and mouse miRNA atlas was supplemented with rat, dog, and chicken datasets. The sixth (latest) edition of the FANTOM project was launched to assess the function of human long non-coding RNAs (lncRNAs). From its creation until 2020, FANTOM6 has contributed to the research community a large dataset generated from the knock-down of 285 lncRNAs in human dermal fibroblasts; this is followed with extensive expression profiling and cellular phenotyping. Other updates to the FANTOM resource includes the reprocessing of the miRNA and promoter atlases of human, mouse and chicken with the latest reference genome assemblies. To facilitate the use and accessibility of all above resources we further enhanced FANTOM data viewers and web interfaces. The updated FANTOM web resource is publicly available at https://fantom.gsc.riken.jp/.
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影响因子：
56.9
作者：
Carninci, P;Kasukawa, T;Hayashizaki, Y
通讯作者：
Hayashizaki, Y
影响因子：
14.9
作者：
Frankish A;Diekhans M;Ferreira AM;Johnson R;Jungreis I;Loveland J;Mudge JM;Sisu C;Wright J;Armstrong J;Barnes I;Berry A;Bignell A;Carbonell Sala S;Chrast J;Cunningham F;Di Domenico T;Donaldson S;Fiddes IT;García Girón C;Gonzalez JM;Grego T;Hardy M;Hourlier T;Hunt T;Izuogu OG;Lagarde J;Martin FJ;Martínez L;Mohanan S;Muir P;Navarro FCP;Parker A;Pei B;Pozo F;Ruffier M;Schmitt BM;Stapleton E;Suner MM;Sycheva I;Uszczynska-Ratajczak B;Xu J;Yates A;Zerbino D;Zhang Y;Aken B;Choudhary JS;Gerstein M;Guigó R;Hubbard TJP;Kellis M;Paten B;Reymond A;Tress ML;Flicek P
通讯作者：
Flicek P
DOI：
10.4018/ijswis.2018010106
发表时间：
2018-01-01
影响因子：
3.2
作者：
Kobayashi, Norio;Kume, Satoshi;Masuya, Hiroshi
通讯作者：
Masuya, Hiroshi
DOI：
10.1126/science.1259418
发表时间：
2015-02-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arner E;Daub CO;Vitting-Seerup K;Andersson R;Lilje B;Drabløs F;Lennartsson A;Rönnerblad M;Hrydziuszko O;Vitezic M;Freeman TC;Alhendi AM;Arner P;Axton R;Baillie JK;Beckhouse A;Bodega B;Briggs J;Brombacher F;Davis M;Detmar M;Ehrlund A;Endoh M;Eslami A;Fagiolini M;Fairbairn L;Faulkner GJ;Ferrai C;Fisher ME;Forrester L;Goldowitz D;Guler R;Ha T;Hara M;Herlyn M;Ikawa T;Kai C;Kawamoto H;Khachigian LM;Klinken SP;Kojima S;Koseki H;Klein S;Mejhert N;Miyaguchi K;Mizuno Y;Morimoto M;Morris KJ;Mummery C;Nakachi Y;Ogishima S;Okada-Hatakeyama M;Okazaki Y;Orlando V;Ovchinnikov D;Passier R;Patrikakis M;Pombo A;Qin XY;Roy S;Sato H;Savvi S;Saxena A;Schwegmann A;Sugiyama D;Swoboda R;Tanaka H;Tomoiu A;Winteringham LN;Wolvetang E;Yanagi-Mizuochi C;Yoneda M;Zabierowski S;Zhang P;Abugessaisa I;Bertin N;Diehl AD;Fukuda S;Furuno M;Harshbarger J;Hasegawa A;Hori F;Ishikawa-Kato S;Ishizu Y;Itoh M;Kawashima T;Kojima M;Kondo N;Lizio M;Meehan TF;Mungall CJ;Murata M;Nishiyori-Sueki H;Sahin S;Nagao-Sato S;Severin J;de Hoon MJ;Kawai J;Kasukawa T;Lassmann T;Suzuki H;Kawaji H;Summers KM;Wells C;FANTOM Consortium;Hume DA;Forrest AR;Sandelin A;Carninci P;Hayashizaki Y
通讯作者：
Hayashizaki Y
影响因子：
64.8
作者：
Hon CC;Ramilowski JA;Harshbarger J;Bertin N;Rackham OJ;Gough J;Denisenko E;Schmeier S;Poulsen TM;Severin J;Lizio M;Kawaji H;Kasukawa T;Itoh M;Burroughs AM;Noma S;Djebali S;Alam T;Medvedeva YA;Testa AC;Lipovich L;Yip CW;Abugessaisa I;Mendez M;Hasegawa A;Tang D;Lassmann T;Heutink P;Babina M;Wells CA;Kojima S;Nakamura Y;Suzuki H;Daub CO;de Hoon MJ;Arner E;Hayashizaki Y;Carninci P;Forrest AR
通讯作者：
Forrest AR