The role of chemoattractant receptors in shaping the tumor microenvironment.
The role of chemoattractant receptors in shaping the tumor microenvironment.
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趋化受体在塑造肿瘤微环境中的作用
DOI：
10.1155/2014/751392
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发表时间：
2014
影响因子：
--
通讯作者：
Wang JM
中科院分区：
文献类型：
--
作者：
Zhou J;Xiang Y;Yoshimura T;Chen K;Gong W;Huang J;Zhou Y;Yao X;Bian X;Wang JM
趋化因子受体（Chemoattractant receptors，CHR）是一个由七种跨膜G蛋白偶联受体（GPCRs）组成的家族，最初被发现介导免疫细胞的趋化和活化。在过去的几十年中，这些GPCR的功能已被发现不仅调节白细胞运输和促进免疫应答，而且在稳态，发育，血管生成和肿瘤进展中发挥重要作用。越来越多的证据表明，化学引诱物GPCR及其配体基于其协调免疫细胞、内皮细胞、成纤维细胞和间充质细胞对肿瘤微环境的浸润的能力而促进恶性肿瘤的进展。这有助于肿瘤细胞与宿主细胞、肿瘤细胞与肿瘤细胞以及宿主细胞与宿主细胞的相互作用，从而为已建立的肿瘤的扩增和远处转移的发展提供基础。此外，许多非造血来源的恶性肿瘤表达多种化学引诱物GPCR，其增加肿瘤细胞的侵袭性和转移。因此，GPCR及其配体构成了开发新型抗肿瘤治疗剂的靶标。
Chemoattractant receptors are a family of seven transmembrane G protein coupled receptors (GPCRs) initially found to mediate the chemotaxis and activation of immune cells. During the past decades, the functions of these GPCRs have been discovered to not only regulate leukocyte trafficking and promote immune responses, but also play important roles in homeostasis, development, angiogenesis, and tumor progression. Accumulating evidence indicates that chemoattractant GPCRs and their ligands promote the progression of malignant tumors based on their capacity to orchestrate the infiltration of the tumor microenvironment by immune cells, endothelial cells, fibroblasts, and mesenchymal cells. This facilitates the interaction of tumor cells with host cells, tumor cells with tumor cells, and host cells with host cells to provide a basis for the expansion of established tumors and development of distant metastasis. In addition, many malignant tumors of the nonhematopoietic origin express multiple chemoattractant GPCRs that increase the invasiveness and metastasis of tumor cells. Therefore, GPCRs and their ligands constitute targets for the development of novel antitumor therapeutics.
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