The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.
The risk of childhood brain tumors associated with delivery interventions: A Danish matched case-control study.
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DOI：
10.1016/j.canep.2021.102077
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发表时间：
2022-03
影响因子：
2.6
通讯作者：
Heck JE
中科院分区：
文献类型：
--
作者：
Yeh KW;He D;Hansen J;Carpenter CL;Ritz B;Olsen J;Heck JE
头部创伤与成人脑肿瘤风险增加有关。器械辅助分娩可能是新生儿头部创伤的一个原因。这项研究的目的是确定在丹麦，器械辅助分娩是否影响儿童脑肿瘤的几率。我们对丹麦1978年至2013年出生并于1978年至2016年诊断的儿童（<20岁）脑肿瘤进行了一项匹配病例对照研究。共确定了1，678例脑肿瘤病例，并根据儿童的性别和出生日期（N= 40，934）将25名对照与每个病例相匹配。条件logistic回归用于估计感兴趣变量的效应（比值比（OR）和95%置信区间（95%CI））。与自然阴道分娩的儿童相比，后来发生室管膜瘤的儿童（N = 118）更有可能经历真空辅助分娩（OR=1.74，95% CI 1.02-2.96）。福美双的使用率很低，在整个研究期间都在下降。我们没有观察到所有CNS肿瘤（合并）在真空递送（OR=0.99，95% CI 0.84-1.18）或产钳递送（OR=1.26，95% CI 0.78-2.03）中的总体增加。我们的研究结果表明真空辅助分娩和室管膜瘤之间存在关联。
Head trauma has been associated with increased brain tumor risk in adults. Instrument assisted delivery can be a cause of head trauma in newborns. The goal of this study was to determine if instrument-assisted deliveries influenced the odds of childhood brain tumors in Denmark. We conducted a matched case-control study of childhood (<20 years) brain tumors in Denmark born between 1978 and 2013 and diagnosed 1978–2016. A total of 1,678 brain tumor cases were identified and 25 controls were matched to each case based on the child’s sex and birth date (N=40,934). Conditional logistic regression was used to estimate effects (odds ratios (OR) and 95% confidence intervals (95%CI)) for variables of interest. Compared to children birthed by spontaneous vaginal delivery, children who later developed ependymomas (N = 118) had a greater likelihood of having experienced vacuum assisted deliveries (OR=1.74, 95% CI 1.02–2.96). Forceps use was low, and declined across the study period. We did not observe an overall increase in all CNS tumors (combined) with either vacuum delivery (OR=0.99, 95% CI 0.84–1.18) or forceps delivery (OR=1.26, 95% CI 0.78–2.03). Our findings suggest an association between vacuum assisted deliveries and ependymomas.
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