Syndecan-4 is correlated with disease activity and serological characteristic of rheumatoid arthritis
Syndecan-4 is correlated with disease activity and serological characteristic of rheumatoid arthritis
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Syndecan-4 与类风湿性关节炎的疾病活动度和血清学特征相关
DOI：
10.1186/s42358-022-00254-3
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发表时间：
2022-06
影响因子：
2.3
通讯作者：
Zhuoli Zhang
中科院分区：
文献类型：
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作者：
Juan Zhao;Xia Ye;Zhuoli Zhang
摘要目的探讨syndecan-4在类风湿关节炎（RA）患者血清、滑液及滑膜中的表达特点，并分析其与RA疾病活动性及血清学特征的相关性。方法采用酶联免疫吸附法（ELISA）检测60例RA患者、20例骨关节炎（OA）患者、20例健康对照者血清及25例RA患者、25例OA患者SF中Syndecan-4的表达。采用免疫组化法检测syndecan-4在RA和OA患者滑膜中的表达。免疫荧光法检测RA和OA患者滑膜成纤维细胞syndecan-4的表达。分析RA患者血清syndecan-4浓度与疾病活动性的相关性。结果RA患者血清syndedcan-4浓度显著高于OA患者和健康对照组，RF阳性RA患者血清syndedcan-4浓度显著高于RF阴性RA患者。RA患者SF中Syndecan-4浓度与OA患者相当。RA和OA患者滑膜组织中Syndecan-4的表达相似。RA和OA患者SF中syndecan-4的浓度显著低于血清。血清和SF中Syndecan-4浓度与RA患者的疾病活动性呈正相关。结论RA患者血清syndecan-4浓度高于OA患者，RF阳性RA患者血清syndecan-4浓度明显高于RF阴性RA患者。血清和SF中Syndecan-4浓度与RA患者的疾病活动性呈正相关。
Abstract Objectives To describe the feature of expression of syndecan-4 in serum, synovial fluid (SF) and synovium in rheumatoid arthritis (RA) patients, and to analyze the correlation of syndecan-4 with disease activity and serological characteristic of RA. Methods Syndecan-4 in sera of 60 RA patients, 20 osteoarthritis (OA) patients, 20 healthy controls, and in SF of 25 RA patients and 25 OA patients were tested by enzyme linked immunosorbant assay. The expressions of syndecan-4 in synovium of RA and OA patients were detected by immunohistochemistry. The expression of syndecan-4 on synovial fibroblasts from RA and OA patients were detected by immunofluorescence. The correlation between serum syndecan-4 concentration and disease activity were analyzed in RA patients. Results The serum syndedcan-4 concentration was significantly higher in RA patients than in OA patients and healthy controls, and was higher in rheumatoid factor (RF)-positive RA patients than in RF-negative ones. Syndecan-4 concentration in SF of RA patients was comparable with OA patients. Syndecan-4 expression in synovial tissue was similar between RA and OA patients. The syndecan-4 concentration was significantly lower in SF than in serum of RA and OA patients. Syndecan-4 concentration in both serum and SF was positively correlated with disease activity of RA patients. Conclusion The serum syndecan-4 concentration was higher in RA patients than in OA patients, and significantly higher in RF-positive RA patients than in RF-negative ones. Syndecan-4 concentration in both serum and SF was positively correlated with disease activity of RA patients.
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影响因子：
5.3
作者：
通讯作者：
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影响因子：
4.8
作者：
Wang, Jianru;Markova, Dessislava;Risbud, Makarand V.
通讯作者：
Risbud, Makarand V.
影响因子：
27.4
作者：
Korb-Pap, Adelheid;Stratis, Athanasios;Redlich, Kurt
通讯作者：
Redlich, Kurt
DOI：
10.1002/(sici)1096-9896(199807)185:3
发表时间：
1998-07
期刊：
The Journal of Pathology
影响因子：
--
作者：
C. Ihling;J. Haendeler;G. Menzel;R. Hess;G. Fraedrich;H. Schaefer;A. Zeiher
通讯作者：
C. Ihling;J. Haendeler;G. Menzel;R. Hess;G. Fraedrich;H. Schaefer;A. Zeiher
影响因子：
10.7
作者：
通讯作者：
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