First case of postmortem study in a patient vaccinated against SARS-CoV-2.
First case of postmortem study in a patient vaccinated against SARS-CoV-2.
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DOI：
10.1016/j.ijid.2021.04.053
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Wilkens L
中科院分区：
文献类型：
--
作者：
Hansen T;Titze U;Kulamadayil-Heidenreich NSA;Glombitza S;Tebbe JJ;Röcken C;Schulz B;Weise M;Wilkens L
一名此前没有接种疫苗的86岁男子接种了第一剂BNT 162 b2 mRNA COVID-19疫苗。4周后，他死于急性肾和呼吸衰竭。虽然他没有出现任何COVID-19特有的症状，但他在去世前对SARS-CoV-2的检测呈阳性。刺突蛋白（S1）抗原结合显示免疫球蛋白（IG）G的显著水平，而核衣壳IgG/IgM未被引发。尸检时，急性支气管肺炎和肾小管衰竭被指定为死亡原因;然而，我们没有观察到COVID-19的任何特征性形态学特征。通过实时聚合酶链反应进行的死后分子定位显示，除肝脏和嗅球外，所有检查的器官（口咽、嗅粘膜、气管、肺、心脏、肾脏和大脑）均存在相关的SARS-CoV-2循环阈值。这些结果可能表明，第一次接种诱导免疫原性，但不是无菌免疫。
A previously symptomless 86-year-old man received the first dose of the BNT162b2 mRNA COVID-19 vaccine. He died 4 weeks later from acute renal and respiratory failure. Although he did not present with any COVID-19-specific symptoms, he tested positive for SARS-CoV-2 before he died. Spike protein (S1) antigen-binding showed significant levels for immunoglobulin (Ig) G, while nucleocapsid IgG/IgM was not elicited. Acute bronchopneumonia and tubular failure were assigned as the cause of death at autopsy; however, we did not observe any characteristic morphological features of COVID-19. Postmortem molecular mapping by real-time polymerase chain reaction revealed relevant SARS-CoV-2 cycle threshold values in all organs examined (oropharynx, olfactory mucosa, trachea, lungs, heart, kidney and cerebrum) except for the liver and olfactory bulb. These results might suggest that the first vaccination induces immunogenicity but not sterile immunity.
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影响因子：
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DOI：
10.1016/j.cgh.2021.01.044
发表时间：
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期刊：
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影响因子：
--
作者：
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