Amyloid positron emission tomography with (18)F-flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease.
Amyloid positron emission tomography with (18)F-flutemetamol and structural magnetic resonance imaging in the classification of mild cognitive impairment and Alzheimer's disease.
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使用 (18)F-氟替他莫进行淀粉样蛋白正电子发射断层扫描和结构磁共振成像对轻度认知障碍和阿尔茨海默病的分类。
DOI：
10.1016/j.jalz.2012.01.006
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Buckley C
中科院分区：
文献类型：
--
作者：
Duara R;Loewenstein DA;Shen Q;Barker W;Potter E;Varon D;Heurlin K;Vandenberghe R;Buckley C
To evaluate the contributions of amyloid-positive (Am+) and medial temporal atrophy–positive (MTA+) scans to the diagnostic classification of prodromal and probable Alzheimer’s disease (AD). 18F-flutemetamol-labeled amyloid positron emission tomography (PET) and magnetic resonance imaging (MRI) were used to classify 10 young normal, 15 elderly normal, 20 amnestic mild cognitive impairment (aMCI), and 27 AD subjects. MTA+ status was determined using a cut point derived from a previous study, and Am+ status was determined using a conservative and liberal cut point. The rates of MRI scans with positive results among young normal, elderly normal, aMCI, and AD subjects were 0%, 20%, 75%, and 82%, respectively. Using conservative cut points, the rates of Am+ scans for these same groups of subjects were 0%, 7%, 50%, and 93%, respectively, with the aMCI group showing the largest discrepancy between Am+ and MTA+ scans. Among aMCI cases, 80% of Am+ subjects were also MTA+, and 70% of amyloid-negative (Am−) subjects were MTA+. The combination of amyloid PET and MTA data was additive, with an overall correct classification rate for aMCI of 86%, when a liberal cut point (standard uptake value ratio = 1.4) was used for amyloid positivity. 18F-flutemetamol PET and structural MRI provided additive information in the diagnostic classification of aMCI subjects, suggesting an amyloid-independent neurodegenerative component among aMCI subjects in this sample.
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影响因子：
14.5
作者：
Pike, Kerryn E.;Savage, Greg;Rowe, Christopher C.
通讯作者：
Rowe, Christopher C.
DOI：
10.1016/s0022-5371(73)80034-9
发表时间：
1973-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
BUSCHKE, H
通讯作者：
BUSCHKE, H
DOI：
10.1016/j.jalz.2010.07.002
发表时间：
2011-07
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Shen Q;Loewenstein DA;Potter E;Zhao W;Appel J;Greig MT;Raj A;Acevedo A;Schofield E;Barker W;Wu Y;Potter H;Duara R
通讯作者：
Duara R
影响因子：
9.9
作者：
Duara, R.;Loewenstein, D. A.;Potter, H.
通讯作者：
Potter, H.
影响因子：
11.2
作者：
Morris, John C.;Roe, Catherine M.;Xiong, Chengjie;Fagan, Anne M.;Goate, Alison M.;Holtzman, David M.;Mintun, Mark A.
通讯作者：
Mintun, Mark A.