Processing-Size Correlations in the Preparation of Magnetic Alginate Microspheres Through Emulsification and Ionic Crosslinking.
Processing-Size Correlations in the Preparation of Magnetic Alginate Microspheres Through Emulsification and Ionic Crosslinking.
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DOI：
10.1016/j.colsurfa.2017.05.058
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发表时间：
2017-09-20
期刊：
影响因子：
--
通讯作者：
Rinaldi C
中科院分区：
文献类型：
--
作者：
Garcia AR;Lacko C;Snyder C;Bohórquez AC;Schmidt CE;Rinaldi C
磁性藻酸盐微球由于其藻酸盐基质而具有生物相容性，并且由于其磁性特性而可通过施加的磁场进行运动控制。因此，它们有潜力用作多种材料的容器，包括药物和治疗剂，促进以相对非侵入性的方式进入生物系统。在这里，磁性海藻酸盐微球是通过乳化和离子交联过程制备的，其中海藻酸盐和氧化铁磁性纳米粒子的混合物最初分散在连续相中，然后通过与钙离子交联分散相将该分散相胶凝成微球。发现所得的磁性藻酸盐微球具有超顺磁性，并通过链形成响应所施加的磁场。研究了剪切速率、藻酸盐浓度和磁性纳米粒子浓度对微球尺寸的影响，目的是根据工艺和配方参数控制微球的尺寸。其中两个参数，剪切速率和藻酸盐浓度，用于将实验结果与分散相比连续相更粘的情况的理论模型相关联。
Magnetic alginate microspheres are biocompatible due to their alginate matrix, and motion-controllable by applied magnetic fields due to their magnetic character. Therefore, they have the potential of being used as vessels to a broad variety of materials, including drugs and therapeutic agents, facilitating entry to biological systems in a relatively non-invasive manner. Here, magnetic alginate microspheres were prepared through an emulsification and ionic cross-linking process, where a mixture of alginate and iron oxide magnetic nanoparticles was initially dispersed in a continuous phase, followed by gelation of this dispersed phase into microspheres by cross-linking the dispersion with calcium ions. The resulting magnetic alginate microspheres were found to be superparamagnetic and to respond to applied magnetic fields by chain formation. The effect of shear rate, alginate concentration, and magnetic nanoparticle concentration on microsphere size was investigated with the aim to control the size of microspheres with respect to process and formulation parameters. Two of these parameters, shear rate and alginate concentration, were used to correlate experimental results with a theoretical model for the case where the dispersed phase is more viscous than the continuous phase.
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DOI：
10.1016/j.jconrel.2008.10.019
发表时间：
2009-02-20
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
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作者：
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