A common neurodynamical mechanism could mediate externally induced and intrinsically generated transitions in visual awareness.
A common neurodynamical mechanism could mediate externally induced and intrinsically generated transitions in visual awareness.
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DOI：
10.1371/journal.pone.0053833
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Deco G
中科院分区：
文献类型：
--
作者：
Panagiotaropoulos TI;Kapoor V;Logothetis NK;Deco G
有意识视觉感知的神经相关性通常在感知多稳定性的范式中进行研究，该范式允许在不变的感官刺激期间进行多种感知解释。知觉内容中这种多重稳定性的来源是什么？从理论的角度来看，确定性和随机力之间的平衡已经被建议为多稳态感知过程中观察到的自发的、内在驱动的感知转变的基础。确定性的力量表示的适应功能选择性神经元群体编码的竞争感知，而随机力量建模为噪声驱动的过程。在这里，我们使用了一个统一的神经元竞争模型来研究动态的适应和噪声过程中的双眼闪光抑制（BFS），一种形式的外部诱导的感知抑制，并将其与动态的内在驱动的交替双眼竞争（BR）。这是第一次，我们使用电生理学，生物学相关的数据来约束感知竞争的模型。具体而言，我们表明，在BFS期间的外侧前额叶皮层（LPFC）的电生理记录中检测到的感知调制神经元群体的平均群体放电模式，限制了外部诱导的感知过渡到分叉周围区域的动态范围，该区域将噪声驱动的吸引子制度与适应驱动的振荡制度分开。最有趣的是，BR期间内在驱动的感知转变的动态范围位于噪声驱动的吸引子区域，其中它与BFS重叠。我们的研究结果表明，神经动力学机制的外部诱导和自发产生的感知交替重叠在一个狭窄的，噪声驱动的区域之前的分叉系统成为适应驱动。
The neural correlates of conscious visual perception are commonly studied in paradigms of perceptual multistability that allow multiple perceptual interpretations during unchanged sensory stimulation. What is the source of this multistability in the content of perception? From a theoretical perspective, a fine balance between deterministic and stochastic forces has been suggested to underlie the spontaneous, intrinsically driven perceptual transitions observed during multistable perception. Deterministic forces are represented by adaptation of feature-selective neuronal populations encoding the competing percepts while stochastic forces are modeled as noise-driven processes. Here, we used a unified neuronal competition model to study the dynamics of adaptation and noise processes in binocular flash suppression (BFS), a form of externally induced perceptual suppression, and compare it with the dynamics of intrinsically driven alternations in binocular rivalry (BR). For the first time, we use electrophysiological, biologically relevant data to constrain a model of perceptual rivalry. Specifically, we show that the mean population discharge pattern of a perceptually modulated neuronal population detected in electrophysiological recordings in the lateral prefrontal cortex (LPFC) during BFS, constrains the dynamical range of externally induced perceptual transitions to a region around the bifurcation separating a noise-driven attractor regime from an adaptation-driven oscillatory regime. Most interestingly, the dynamical range of intrinsically driven perceptual transitions during BR is located in the noise-driven attractor regime, where it overlaps with BFS. Our results suggest that the neurodynamical mechanisms of externally induced and spontaneously generated perceptual alternations overlap in a narrow, noise-driven region just before a bifurcation where the system becomes adaptation-driven.
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