Leptin actions on the reproductive neuroendocrine axis in sheep.
Leptin actions on the reproductive neuroendocrine axis in sheep.
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瘦素对绵羊生殖神经内分泌轴的作用。
DOI：
10.1530/biosciprocs.5.021
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
David W Miller
中科院分区：
文献类型：
--
作者：
C. Adam;Archer Za;David W Miller
关于瘦素在反刍动物食欲和神经内分泌调节中的作用的文献越来越多。循环瘦素浓度是高脂肪比瘦羊，是减少慢性喂养不足，是较高的羊进行长日照，而不是短日照。瘦素在空腹时急剧减少，在餐后增加，因此全身瘦素信号有长期和短期成分。生殖神经内分泌输出的营养刺激与瘦素循环浓度增加有关;外周瘦素给药恢复禁食绵羊LH分泌，瘦素对青春期是允许的（尽管不是触发因素）。脑室内（i.c.v.）药理学瘦素输注在营养不良的羊中刺激LH，但在营养良好的羊中不刺激LH，并减少营养良好的羊的食物摄入。单次i.c.v.药物注射或生理输注瘦素刺激LH在良好喂养的绵羊，伴随或不伴随食欲下降。此外，这些食欲和LH反应的差异受光周期的影响，表明不同的神经通路可能介导的两个反应。下丘脑瘦素受体与食欲和食欲神经元共定位，其中一些接触GnRH细胞，但瘦素信号传导与光周期（褪黑激素）信号传导的汇合仍未解决。光周期诱导羊提供了潜在的模型改变中央瘦素的敏感性，其中调节食欲和GnRH的下游机制可能是分离的。
There is a growing literature on the role of leptin in appetite and neuroendocrine regulation in domestic ruminants. Circulating leptin concentration is higher in fat than in thin sheep, is reduced by chronic underfeeding and is higher in sheep subjected to long-day rather than short-day photoperiods. Leptin is reduced acutely by fasting and increases after meals so that there are long- and short-term components to the systemic leptin signal. Nutritional stimulation of reproductive neuroendocrine output is associated with increased circulating concentrations of leptin; peripheral leptin administration restores LH secretion in fasted sheep, and leptin is permissive (although not a trigger) for puberty. Intracerebroventricular (i.c.v.) pharmacological leptin infusion stimulates LH in underfed but not in well-fed sheep, and reduces food intake in well-fed sheep. A single i.c.v. pharmacological injection or physiological infusion of leptin stimulates LH in well-fed sheep, with or without a concomitant decrease in appetite. Furthermore, these appetite and LH responses are differentially affected by photoperiod, indicating that different neuronal pathways may mediate the two responses. Hypothalamic leptin receptors co-localize with orexigenic and anorexigenic neurones, some of which contact GnRH cells, but the confluence of leptin signalling with photoperiod (melatonin) signalling remains unresolved. Photoperiod-entrained sheep provide potential models of altered central leptin sensitivity, in which downstream mechanisms regulating appetite and GnRH may be dissociated.
影响因子：
4.8
作者：
Nagatani, S;Zeng, YH;Jaffe, CA
通讯作者：
Jaffe, CA
影响因子：
3.6
作者：
Foster, DL;Nagatani, S
通讯作者：
Nagatani, S