Sex Differences in the Genetic and Environmental Influences on Self-Reported Non-aggressive and Aggressive Conduct Disorder Symptoms in Early and Middle Adolescence.
Sex Differences in the Genetic and Environmental Influences on Self-Reported Non-aggressive and Aggressive Conduct Disorder Symptoms in Early and Middle Adolescence.
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DOI：
10.1007/s10519-018-9907-1
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发表时间：
2018-07
影响因子：
2.6
通讯作者：
Lahey BB
中科院分区：
文献类型：
--
作者：
Van Hulle CA;Waldman I;Lahey BB
对品行障碍 (CD) 病因学的数十年研究尚未就潜在遗传和环境影响中存在性别差异达成共识。这可能部分是由于许多先前的研究未能区分非攻击性和攻击性克罗恩病症状或测试行为问题病因中性别差异的潜在发育变化。为了解决这些差距，我们将一系列单变量和双变量生物特征性别差异模型与社区双胞胎样本（N = 1,548，年龄 9-17 岁）中自我报告的非攻击性和攻击性 CD 症状进行拟合，样本分为 9-13 岁和 14-17 岁。使用有利于简约的贝叶斯信息准则 (BIC) 和卡方差异检验来评估相对模型拟合度。单变量性别标量模型提供了最适合 9-13 岁和 14-17 岁非攻击性和攻击性 CD 症状的数据。因此，相同的遗传和环境因素影响两性的克罗恩病症状，但女性的总变异性低于男性。在这两个年龄段，非攻击性 CD 症状的遗传力均低于攻击性 CD 症状的遗传力，并且仅在非攻击性 CD 症状中观察到共同的环境影响。然而，对于任一 CD 亚型，遗传和环境因素的估计值在不同年龄组中可能并不相同，这表明遗传和环境因素对 CD 症状个体差异的相对影响发生了实质性的发展变化。对于这两种亚型，老年组的遗传力比年轻组的遗传力更大，而共同的环境影响更小。双变量定量性别差异模型最适合 9-13 岁的数据。非攻击性和攻击性 CD 症状之间的协变是由于男性和女性的共享和非共享环境因素重叠造成的，但男性的总体协变大于女性。相比之下，在 14-17 岁时，性别标量双变量模型提供了最适合的数据，非攻击性和攻击性 CD 症状之间的协变是由于重叠的遗传因素和非共享的环境因素造成的。因此，自我报告的行为障碍的病因因症状类型和年龄的不同而有很大差异。然而，仅当考虑两种亚型之间的协变时，数量上的性别差异才明显。
Decades of research into the etiology of conduct disorder (CD) has yet to yield a consensus on the existence of sex differences in underlying genetic and environmental influences. This may be partly due to the failure of many previous studies to make a distinction between non-aggressive and aggressive CD symptoms or test for potential developmental changes in sex differences in the etiology of conduct problems. To address these gaps, we fit a series of univariate and bivariate biometric sex-difference models to self-reported non-aggressive and aggressive CD symptoms in a community-based sample of twins (N=1,548, ages 9-17 year), grouped into ages 9-13 years and 14-17 years. Relative model fit was evaluated using the Bayesian Information Criterion (BIC), which favors parsimony, and by chi-square difference tests. The univariate sex-scalar model provided the best fit to the data for both non-aggressive and aggressive CD symptoms at ages 9-13 years and 14-17 years. Thus, the same genetic and environmental factors influenced CD symptoms in both sexes, but the total variability was lower in females than males. At both ages, the heritability of non-aggressive CD symptoms was lower than heritability of aggressive CD symptoms, and shared environmental effects were only observed for non-aggressive CD symptoms. However, estimates for genetic and environmental factors could be not be constrained to be equal across age groups for either CD subtype, suggesting substantive developmental changes in the relative influence of genetic and environmental factors on individual differences in CD symptoms. For both subtypes, the heritability was larger, and shared environmental effect smaller, in the older age group than the younger age group. A bivariate quantitative sex differences model provided the best fit to the data at ages 9-13 years. Covariation between non-aggressive and aggressive CD symptoms was due to overlapping shared and non-shared environmental factors in males and females but the overall covariation was greater in males than females. In contrast, at ages 14-17 years, the sex-scalar bivariate model provided the best fit to the data, and covariation between non-aggressive and aggressive CD symptoms was due to overlapping genetic and non-shared environmental factors. Thus, the etiology of self-reported conduct disorder varied substantially by symptom type and age. However, quantitative sex differences were only apparent when the covariation between the two subtypes was considered.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
2.6
作者：
Rathouz, Paul J.;Van Hulle, Carol A.;Lahey, Benjamin B.
通讯作者：
Lahey, Benjamin B.
DOI：
10.1002/ajmg.b.30045
发表时间：
2004-08-15
影响因子：
2.8
作者：
Button, TMM;Scourfield, J;McGuffin, P
通讯作者：
McGuffin, P
影响因子：
3.6
作者：
Lahey, Benjamin B.;Van Hulle, Carol A.;Keenan, Kate
通讯作者：
Keenan, Kate
影响因子：
3.6
作者：
Crick, Nicki R.;Ostrov, Jamie M.;Werner, Nicole E.
通讯作者：
Werner, Nicole E.