Surveillance and Monitoring Techniques for HPV-Related Head and Neck Squamous Cell Carcinoma: Circulating Tumor DNA.
Surveillance and Monitoring Techniques for HPV-Related Head and Neck Squamous Cell Carcinoma: Circulating Tumor DNA.
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DOI：
10.1007/s11864-021-00821-8
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发表时间：
2021-02-08
影响因子：
4.3
通讯作者：
Swiecicki PL
中科院分区：
文献类型：
--
作者：
Dermody SM;Haring CT;Bhambhani C;Tewari M;Brenner JC;Swiecicki PL
人乳头状瘤病毒（HPV）相关的头颈癌的患病率正在上升，优先影响年轻患者并产生长期毒性。尽管如此，没有筛选测试或临床生物标志物用于治疗监测。HPV循环肿瘤DNA（HPV ctDNA）代表了一种新的循环生物标志物，可提供肿瘤对治疗的反应和复发的实时评估。早期的工作表明，这种检测方法有望在许多临床环境中作为预测性生物标志物，即局部晚期疾病放化疗后复发的风险。将这些发现推广到临床将需要该领域的合作努力，包括分析测试特征的技术协调，对接受标准治疗的患者的正常动力学的理解，以及在临床实施之前适当设计的III期试验。如果成功，HPV ctDNA有可能彻底改变临床试验治疗模式并改变患者护理。
Human papilloma virus (HPV) related head and neck cancer is rising in prevalence, preferentially affecting young patients and imparting long term toxicities. Despite this, there are no screening tests or clinical biomarkers for treatment monitoring. HPV circulating tumor DNA (HPV ctDNA) represents a novel circulating biomarker which may provide real-time assessment of tumor response to therapy and recurrence. Early work suggests the promise of this assay as a predictive biomarker in numerous clinical settings, namely risk of recurrence after chemoradiation in locally advanced disease. Advancement of these findings to the clinic will require a collaborative effort in the field, including technical harmonization of assay testing characteristics, understanding of the normal kinetics in patients being treated with standard of care therapies, and appropriately designed phase III trials prior to implementation in the clinic. If successful, HPV ctDNA has the potential to revolutionize clinical trial treatment paradigms and transform patient care.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
10.1007/s10555-017-9685-x
发表时间：
2017-09
期刊：
Cancer metastasis reviews
影响因子：
--
作者：
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通讯作者：
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