Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice.
Kinetics of Postpartum Mesenteric Artery Structure and Function Relative to Pregnancy and Lactation in Mice.
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DOI：
10.1007/s43032-020-00402-4
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Bonney EA
中科院分区：
文献类型：
--
作者：
Gokina NI;Fairchild RI;Bishop NM;Dawson TE;Prakash K;Bonney EA
流行病学证据表明，妇女正常怀孕与晚年心血管风险降低有关。临床研究提供的证据表明，血管功能和结构的变化是可检测的长期后交付。为了理解这些发现，我们检查了与妊娠晚期（LP）和哺乳期相关的产后（PP）早期（3天和2-4周）和晚期（12周）肠系膜动脉反应性。测试了来自处女对照、LP、PP以及哺乳和非哺乳母亲的血管对苯肾上腺素（PE）、高钾溶液（高K+）和乙酰胆碱（ACh）的反应。对研究组的被动动脉扩张性、血管尺寸、胶原蛋白和弹性蛋白含量进行评价。结果表明：（1）PE可明显抑制LP、PP 3天和PP 2周的血管反应性，PP 4和12周时可恢复到妊娠前水平;（2）抑制PP血管NO的产生可使PE引起的收缩恢复到妊娠前水平;（4）LP和早期PP与动脉扩张性的持续增加相关，这与PP诱导的壁胶原减少相关，并且在PP 12周时回归到孕前水平;（5）非哺乳PP小鼠的血管表现出PE反应性增加，对ACh的反应减弱，并且与母乳喂养的小鼠相比膨胀性降低。这些研究提供了妊娠期间发生的肠系膜动脉适应的时间范围，并延伸至PP期，但可能因PP事件而改变。在线版本包含补充材料，可通过10.1007/s43032-020-00402-4获得。
Epidemiological evidence suggests that normal pregnancy in women is associated with decreased cardiovascular risk in later life. Clinical studies have provided evidence that alterations in vascular function and structure are detectable long after delivery. To understand these findings, we examined mesenteric artery reactivity at both early (3 days and 2–4 weeks) and late (12 weeks) postpartum (PP) time points in relation to late pregnancy (LP) and lactation. Vessels from virgin controls, LP, PP, and nursing and non-nursing mothers were tested for responses to phenylephrine (PE), high potassium solutions (high K+), and acetylcholine (ACh). Passive arterial distensibility, vessel dimensions, and collagen and elastin content were evaluated for the studied groups. We observed that (1) there was a significant inhibition of vascular reactivity to PE in LP, 3 days and 2 weeks PP vessels that returned to pre-pregnancy levels at 4 and 12 weeks PP; (2) inhibition of NO production in PP vessels restored PE-induced constriction to pre-pregnancy levels; (3) vasodilator responses to ACh were similar at all PP periods; (4) LP and early PP was associated with a persistent increase in arterial distensibility that correlates with a PP-induced reduction in wall collagen, and regressed to pre-conception levels at 12 weeks PP; (5) vessels from non-nursing PP mice demonstrated an increased PE reactivity, diminished responses to ACh, and reduced distensibility compared to breastfeeding mice. These studies provide a timeframe for mesenteric artery adaptations that occur during pregnancy and extend to the PP period, but which may be modified by PP events. The online version contains supplementary material available at 10.1007/s43032-020-00402-4.
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