Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency.
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DOI：
10.1016/j.neurobiolaging.2018.06.039
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发表时间：
2018-11
影响因子：
4.2
通讯作者：
Elliott MH
中科院分区：
文献类型：
--
作者：
Reagan AM;Gu X;Paudel S;Ashpole NM;Zalles M;Sonntag WE;Ungvari Z;Csiszar A;Otalora L;Freeman WM;Stout MB;Elliott MH
脑微循环对于保持大脑健康至关重要，血管损伤与年龄相关的神经退行性疾病有关。因为视网膜是中枢神经系统的组成部分，所以在老化视网膜中发生的细胞变化可能与老化的大脑相关，并且视网膜提供了整个血管床可见的优点。在这项研究中，我们测试的假设，正常，健康的老龄化改变收缩血管平滑肌细胞（VSMC）覆盖的视网膜小动脉。我们发现，老化的结果在一个显着减少的收缩VSMCs的局灶性补丁沿着小动脉。在缺乏衰老相关蛋白小窝蛋白-1（Cav-1）的小鼠中，收缩性VSMC的局灶性丧失发生在较年轻的年龄。胰岛素样生长因子-1（IGF-1）的遗传缺失不会加剧血管紧张素Ⅱ相关的收缩性VSMC损失。收缩性VSMC的斑片状损失为先前的临床研究提供了细胞解释，这些临床研究显示健康老年人受试者视网膜小动脉反应性中的局灶性微不规则性，并且可能导致与年龄相关的视网膜血管并发症。
Cerebral microcirculation is critical for the preservation of brain health and vascular impairment is associated with age-related neurodegenerative diseases. Because the retina is a component of the central nervous system, cellular changes that occur in the aging retina are likely relevant to the aging brain and the retina provides the advantage that the entire vascular bed is visible, en face. In this study, we tested the hypothesis that normal, healthy aging alters the contractile vascular smooth muscle cell (VSMC) coverage of retinal arterioles. We found that aging results in a significant reduction of contractile VSMCs in focal patches along arterioles. Focal loss of contractile VSMCs occurs at a younger age in mice deficient in the senescence-associated protein, caveolin-1 (Cav-1). Age-related contractile VSMC loss is not exacerbated by genetic depletion of insulin-like growth factor-1 (IGF-1). The patchy loss of contractile VSMCs provides a cellular explanation for previous clinical studies showing focal microirregularities in retinal arteriolar responsiveness in healthy aged human subjects and is likely to contribute to age-related retinal vascular complications.
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DOI：
10.1002/jbmr.2689
发表时间：
2016-02
期刊：
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
影响因子：
--
作者：
Ashpole NM;Herron JC;Mitschelen MC;Farley JA;Logan S;Yan H;Ungvari Z;Hodges EL;Csiszar A;Ikeno Y;Humphrey MB;Sonntag WE
通讯作者：
Sonntag WE
影响因子：
6
作者：
Csiszar, Anna;Labinskyy, Nazar;Ungvari, Zoltan
通讯作者：
Ungvari, Zoltan
影响因子：
4.2
作者：
Klein, R;Klein, BEK;Wong, TY
通讯作者：
Wong, TY
影响因子：
20.1
作者：
Liu H;Zhang W;Kennard S;Caldwell RB;Lilly B
通讯作者：
Lilly B
影响因子：
--
作者：
Feng, Yuxi;Pfister, Frederick;Hammes, Hans-Peter
通讯作者：
Hammes, Hans-Peter