Tea polyphenols and their roles in cancer prevention and chemotherapy.
Tea polyphenols and their roles in cancer prevention and chemotherapy.
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DOI：
10.3390/ijms9071196
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发表时间：
2008-06
影响因子：
5.6
通讯作者：
Dou QP
中科院分区：
文献类型：
--
作者：
Chen D;Dou QP
许多植物来源的膳食多酚已被研究用于化学预防和化学治疗人类癌症的特性，包括绿茶多酚、染料木素（在大豆中发现）、芹菜素（芹菜、欧芹）、木犀草素（西兰花）、槲皮素（洋葱）、山酚（西兰花、葡萄柚）、姜黄素（姜黄）等。我们对它们所涉及的分子机制和细胞靶点了解得越多，我们就能更好地利用这些“天赋”来预防和治疗人类癌症。此外，更好地了解它们的构效关系将指导合成具有更高生物利用度、稳定性、效力和特异性的类似物。本文以绿茶多酚为重点，综述了近年来报道的茶多酚在人类癌症系统中的生物学作用，重点介绍了已发现的茶多酚的分子靶点和途径，并讨论了茶多酚在预防和治疗人类癌症中的作用。本文还简要介绍了其他几种膳食多酚及其在癌症预防和化疗中的生物学作用。
Many plant-derived, dietary polyphenols have been studied for their chemopreventive and chemotherapeutic properties against human cancers, including green tea polyphenols, genistein (found in soy), apigenin (celery, parsley), luteolin (broccoli), quercetin (onions), kaempferol (broccoli, grapefruits), curcumin (turmeric), etc. The more we understand their involved molecular mechanisms and cellular targets, the better we could utilize these “natural gifts” for the prevention and treatment of human cancer. Furthermore, better understanding of their structure-activity relationships will guide synthesis of analog compounds with improved bio-availability, stability, potency and specificity. This review focuses on green tea polyphenols and seeks to summarize several reported biological effects of tea polyphenols in human cancer systems, highlight the molecular targets and pathways identified, and discuss the role of tea polyphenols in the prevention and treatment of human cancer. The review also briefly describes several other dietary polyphenols and their biological effects on cancer prevention and chemotherapy.
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DOI：
10.1196/annals.1323.027
发表时间：
2005-01-01
期刊：
LONGEVITY HEALTH SCIENCES: THE PHOENIX CONFERENCE
影响因子：
--
作者：
Cutler, RG
通讯作者：
Cutler, RG
影响因子：
3.5
作者：
Adams, BK;Ferstl, EM;Shoji, M
通讯作者：
Shoji, M
影响因子：
2.9
作者：
Balasubramanyam, M;Koteswari, AA;Mohan, V
通讯作者：
Mohan, V
影响因子：
12.4
作者：
An, B;Goldfarb, RH;Dou, QP
通讯作者：
Dou, QP
影响因子：
3.1
作者：
Chen, Di;Chen, Marina S.;Dou, Q. Ping
通讯作者：
Dou, Q. Ping