The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer's Disease.
The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer's Disease.
复制标题
DOI：
10.3389/fcell.2020.594998
复制
发表时间：
2020
影响因子：
5.5
通讯作者：
Jia Z
中科院分区：
文献类型：
--
作者：
Ben Zablah Y;Merovitch N;Jia Z
肌动蛋白解聚因子(ADF)/cofilin是一个肌动蛋白结合蛋白家族，在响应各种信号的肌动蛋白重组调控中起关键作用。越来越多的证据表明，ADF/cofilin也在神经元结构和功能中发挥重要作用，包括长期增强和抑郁。这些是长期突触可塑性研究最广泛的形式，被广泛认为是学习和记忆的细胞机制。ADF/cofilin通过影响树突棘和谷氨酸受体的运输来调节突触功能，谷氨酸受体是脊椎动物兴奋性突触传递的主要介质。ADF/cofilin的调控涉及多种信号通路，这些信号通路聚集在LIM结构域激酶和弹弓磷酸酶上，分别使ADF/cofilin磷酸化/失活和去磷酸化/激活。肌动蛋白解聚因子/cofilin活性也受其他肌动蛋白结合蛋白、活性依赖性亚细胞分布和蛋白质翻译的调节。ADF/cofilin异常与几种神经退行性疾病（如阿尔茨海默病）有关。因此，研究ADF/cofilin在大脑中的作用不仅对理解控制神经元结构和功能的基本过程具有重要意义，而且可能为治疗脑部疾病提供潜在的治疗策略。
Actin-depolymerization factor (ADF)/cofilin, a family of actin-binding proteins, are critical for the regulation of actin reorganization in response to various signals. Accumulating evidence indicates that ADF/cofilin also play important roles in neuronal structure and function, including long-term potentiation and depression. These are the most extensively studied forms of long-lasting synaptic plasticity and are widely regarded as cellular mechanisms underlying learning and memory. ADF/cofilin regulate synaptic function through their effects on dendritic spines and the trafficking of glutamate receptors, the principal mediator of excitatory synaptic transmission in vertebrates. Regulation of ADF/cofilin involves various signaling pathways converging on LIM domain kinases and slingshot phosphatases, which phosphorylate/inactivate and dephosphorylate/activate ADF/cofilin, respectively. Actin-depolymerization factor/cofilin activity is also regulated by other actin-binding proteins, activity-dependent subcellular distribution and protein translation. Abnormalities in ADF/cofilin have been associated with several neurodegenerative disorders such as Alzheimer’s disease. Therefore, investigating the roles of ADF/cofilin in the brain is not only important for understanding the fundamental processes governing neuronal structure and function, but also may provide potential therapeutic strategies to treat brain disorders.
影响因子：
3
作者：
Lamprecht R
通讯作者：
Lamprecht R