The roles of the actin cytoskeleton in fear memory formation.
The roles of the actin cytoskeleton in fear memory formation.
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DOI：
10.3389/fnbeh.2011.00039
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发表时间：
2011
影响因子：
3
通讯作者：
Lamprecht R
中科院分区：
文献类型：
--
作者：
Lamprecht R
在随后的恐惧事件中，恐惧记忆的形成和储存是适应行为和避免危险所必需的。然而，恐惧记忆也可能在压力和焦虑症中发挥重要作用。当恐惧变得与应对特定刺激的必要程度不成比例时，或者开始在不适当的情况下发生，就存在恐惧或焦虑症。因此，对支撑恐惧记忆的细胞和分子机制的研究可能有助于揭示记忆的形成以及焦虑和压力相关的障碍。有证据表明，恐惧学习会导致恐惧记忆形成的大脑区域，包括杏仁核和海马体，神经元突触传递和形态发生变化。肌动蛋白细胞骨架已被证明参与了这些关键的神经元过程。最近的发现表明，肌动蛋白细胞骨架是恐惧、记忆形成和消亡所必需的。此外，肌动蛋白细胞骨架参与了突触的可塑性和大脑中介导恐惧记忆的神经元的形态发生。因此，肌动蛋白细胞骨架可能在恐惧学习过程中的突触传递和恐惧记忆形成所必需的长期细胞变化之间起中介作用。
The formation and storage of fear memory is needed to adapt behavior and avoid danger during subsequent fearful events. However, fear memory may also play a significant role in stress and anxiety disorders. When fear becomes disproportionate to that necessary to cope with a given stimulus, or begins to occur in inappropriate situations, a fear or anxiety disorder exists. Thus, the study of cellular and molecular mechanisms underpinning fear memory may shed light on the formation of memory and on anxiety and stress related disorders. Evidence indicates that fear learning leads to changes in neuronal synaptic transmission and morphology in brain areas underlying fear memory formation including the amygdala and hippocampus. The actin cytoskeleton has been shown to participate in these key neuronal processes. Recent findings show that the actin cytoskeleton is needed for fear memory formation and extinction. Moreover, the actin cytoskeleton is involved in synaptic plasticity and in neuronal morphogenesis in brain areas that mediate fear memory. The actin cytoskeleton may therefore mediate between synaptic transmission during fear learning and long-term cellular alterations mandatory for fear memory formation.
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影响因子：
2.9
作者：
Amano, Mutsuki;Nakayama, Masanori;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
影响因子：
64.8
作者：
Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
通讯作者：
Luethi, Andreas
影响因子：
2
作者：
Collins, DR;Paré, D
通讯作者：
Paré, D
DOI：
10.1083/jcb.200212140
发表时间：
2003-05-26
期刊：
The Journal of cell biology
影响因子：
--
作者：
Bloom O;Evergren E;Tomilin N;Kjaerulff O;Löw P;Brodin L;Pieribone VA;Greengard P;Shupliakov O
通讯作者：
Shupliakov O
DOI：
10.1073/pnas.0610059104
发表时间：
2007-01-09
影响因子：
11.1
作者：
Diana, Giovanni;Valentini, Giovanni;Fiorentini, Carla
通讯作者：
Fiorentini, Carla