A Meta-Analysis of Nucleos(t)ide Analogues in Patients with Decompensated Cirrhosis Due to Hepatitis B
A Meta-Analysis of Nucleos(t)ide Analogues in Patients with Decompensated Cirrhosis Due to Hepatitis B
复制标题
乙型肝炎失代偿性肝硬化患者核苷（酸）类似物的荟萃分析
DOI：
10.1007/s10620-012-2414-y
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发表时间：
2013-03
影响因子：
3.1
通讯作者：
Shen Xizhong
中科院分区：
文献类型：
--
作者：
Huang Yingnan;Wu Hao;Wu Shengdi;Fu Da;Ma Y;Shen Xizhong
Background:The effect of nucleos(t)ide analogues therapy in patients with decompensated cirrhosis remains unclear.Aim:The purpose of this study was to evaluate the effect of nucleos(t)ide analogues on decompensated cirrhotic patients.Methods:An online search within PubMed, Web of Science, Embase, Cochrane Central of Register of Controlled Trials and China Biology Medicine disc from 1998-01-01 to 2011-09-05 was conducted. A meta-analysis was performed. Relative risks of mortality rate, Child-Pugh-Turcotte score and hepatitis B e-antigen (HBeAg) seroconversion of the decompensated patients were studied.Results:Eight studies involving 511 patients were included. Data showed that lamivudine and telbivudine significantly decreased the mortality rate (relative risk 0.36, 95 % confidence interval 0.25-0.54), improved the Child-Pugh-Turcotte scores (mean difference -3.23, 95 % confidence interval -3.98 to -2.48) and promoted HBeAg seroconversion (relative risk 7.48, 95 % confidence interval 2.31-24.20).Conclusion:For patients with decompensated cirrhosis, lamivudine and telbivudine significantly decrease the mortality rate and disease severity. Also, they promote their HBeAg seroconversion.
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影响因子：
11.8
作者：
Lai, CL;Dienstag, J;Condreay, L
通讯作者：
Condreay, L
影响因子：
11.4
作者：
Steve McDonald
通讯作者：
Steve McDonald
影响因子：
9.8
作者：
S. Manolakopoulos;S. Karatapanis;J. Elefsiniotis;N. Mathou;J. Vlachogiannakos;E. Iliadou;Anastasios Kougioumtzan;M. Economou;C. Triantos;D. Tzourmakliotis;A. Avgerinos
通讯作者：
S. Manolakopoulos;S. Karatapanis;J. Elefsiniotis;N. Mathou;J. Vlachogiannakos;E. Iliadou;Anastasios Kougioumtzan;M. Economou;C. Triantos;D. Tzourmakliotis;A. Avgerinos
影响因子：
29.4
作者：
Iloeje, UH;Yang, HI;Chen, CJ
通讯作者：
Chen, CJ
影响因子：
4.6
作者：
Hann, HWL;Fontana, RJ;Griffiths, D
通讯作者：
Griffiths, D