The Cam‐Path Forward

Lymphocyte depletion has been a tool in the transplant clinician’s armamentarium since the earliest days of the field. Whether it is a “good” tool or not is largely dependent on how and when it is used, with the dominant consideration being the risk-benefit balance between rejection and opportunistic infection or malignancy. In general, lymphocyte depletion has been shown to reduce the rate of acute rejection and to reverse allograft rejection in numerous settings; its long-term benefits are less clearly established. Regardless, lymphocyte depletion is an established part of transplantation.

自移植领域诞生之初，淋巴细胞清除就一直是移植临床医生的一种手段。它是否是一种“好”的手段在很大程度上取决于如何以及何时使用，主要考虑的是排斥反应与机会性感染或恶性肿瘤之间的风险 - 收益平衡。一般来说，在许多情况下，淋巴细胞清除已被证明可以降低急性排斥反应的发生率并逆转同种异体移植排斥反应；其长期益处尚不明确。无论如何，淋巴细胞清除是移植中既定的一部分。