Relapse or reinfection: Classification of malaria infection using transition likelihoods.
Relapse or reinfection: Classification of malaria infection using transition likelihoods.
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作者：
Lin FC;Li Q;Lin JT
间日疟原虫疟疾患者经有效血期治疗后，可能因肝期潜伏感染复发或蚊虫叮咬后再次感染而复发。在评估抗复发治疗的疗效时，将复发感染分类为复发或再感染是至关重要的。尽管人们可以使用基线和复发基因型之间是否存在共享遗传变异来对结果进行分类，但很少有人建议同时使用共享和非共享变异来提高分类准确性。在本文中，我们开发了一种新的分类标准，利用转移可能性来区分复发和再感染。当在已知结果的广泛模拟实验中进行测试时，我们的分类器具有优越的操作特性。分析了来自78名柬埔寨间日疟患者的真实数据集，以证明我们提出的方法的实际用途。
In patients with Plasmodium vivax malaria treated with effective blood-stage therapy, the recurrent illness may occur due to relapse from latent liver-stage infection or reinfection from a new mosquito bite. Classification of the recurrent infection as either relapse or reinfection is critical when evaluating the efficacy of an anti-relapse treatment. Although one can use whether a shared genetic variant exists between baseline and recurrence genotypes to classify the outcome, little has been suggested to use both sharing and nonsharing variants to improve the classification accuracy. In this paper, we develop a novel classification criterion that utilizes transition likelihoods to distinguish relapse from reinfection. When tested in extensive simulation experiments with known outcomes, our classifier has superior operating characteristics. A real data set from 78 Cambodian P. vivax malaria patients was analyzed to demonstrate the practical use of our proposed method.
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影响因子：
6.4
作者：
Imwong, Mallika;Snounou, Georges;White, Nicholas J.
通讯作者：
White, Nicholas J.
影响因子：
6.4
作者：
Juliano, Jonathan J.;Ariey, Frederic;Meshnick, Steven R.
通讯作者：
Meshnick, Steven R.
影响因子：
14.9
作者：
Hathaway NJ;Parobek CM;Juliano JJ;Bailey JA
通讯作者：
Bailey JA
DOI：
10.1073/pnas.1007068107
发表时间：
2010-11-16
影响因子：
11.1
作者：
Juliano, Jonathan J.;Porter, Kimberly;Meshnick, Steven R.
通讯作者：
Meshnick, Steven R.
影响因子：
4.9
作者：
Kwiek, Jesse J.;Alker, Alisa P.;Meshnick, Steven R.
通讯作者：
Meshnick, Steven R.