Gene expression profiling in human lung development: an abundant resource for lung adenocarcinoma prognosis.
Gene expression profiling in human lung development: an abundant resource for lung adenocarcinoma prognosis.
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DOI：
10.1371/journal.pone.0105639
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Cheng S
中科院分区：
文献类型：
--
作者：
Feng L;Wang J;Cao B;Zhang Y;Wu B;Di X;Jiang W;An N;Lu D;Gao S;Zhao Y;Chen Z;Mao Y;Gao Y;Zhou D;Jen J;Liu X;Zhang Y;Li X;Zhang K;He J;Cheng S
肿瘤可以被视为一种特殊的“器官”，它经历异常且调节不良的器官发生。通过重新检查正常发育过程中运作的独特过程，可能会促进癌症预后和治疗的进展，以阐明被其异质性显着掩盖的癌症的内在特征。使用微阵列对来自亚洲血统的处于四个发育阶段的 44 个人类肺组织和来自华裔患者的 69 个肺腺癌 (ADC) 组织样本的整体基因表达特征进行了分析。所有基因根据其在发育过程中的表达模式（命名为PTN1至PTN27）被分为27个不同的组。在肺ADC中，在肺发育过程中表达水平稳定下降的基因（PTN1中的基因）通常会重新激活表达，而表达水平均匀增加的基因（PTN27中的基因）则表达受到抑制。 PTN1 中的基因包含许多对肺 ADC 具有预后价值的 n 基因特征。 12 基因演示物与患者生存的预后相关性在五组健康患者和 ADC 患者中进行了表征 [ADC_CICAMS (n = 69, p = 0.007)、ADC_PNAS (n = 125, p = 0.0063)、ADC_GSE13213 (n = 117，p = 0.0027)、ADC_GSE8894 (n = 62，p = 0.01) 和 ADC_NCI (n = 282，p = 0.045)] 和四组 I 期患者 [ADC_CICAMS (n = 22，p = 0.017)、ADC_PNAS (n = 76，p = 0.018)、ADC_GSE13213 (n = 79，p = 0.02) 和 ADC_qPCR (n = 62， p = 0.006)]。总之，通过比较人肺发育过程和肺 ADC 进展期间的基因表达谱，我们发现在肺发育过程中表达模式均匀下降的基因对于肺 ADC 具有巨大的预后价值。
A tumor can be viewed as a special “organ” that undergoes aberrant and poorly regulated organogenesis. Progress in cancer prognosis and therapy might be facilitated by re-examining distinctive processes that operate during normal development, to elucidate the intrinsic features of cancer that are significantly obscured by its heterogeneity. The global gene expression signatures of 44 human lung tissues at four development stages from Asian descent and 69 lung adenocarcinoma (ADC) tissue samples from ethnic Chinese patients were profiled using microarrays. All of the genes were classified into 27 distinct groups based on their expression patterns (named as PTN1 to PTN27) during the developmental process. In lung ADC, genes whose expression levels decreased steadily during lung development (genes in PTN1) generally had their expression reactivated, while those with uniformly increasing expression levels (genes in PTN27) had their expression suppressed. The genes in PTN1 contain many n-gene signatures that are of prognostic value for lung ADC. The prognostic relevance of a 12-gene demonstrator for patient survival was characterized in five cohorts of healthy and ADC patients [ADC_CICAMS (n = 69, p = 0.007), ADC_PNAS (n = 125, p = 0.0063), ADC_GSE13213 (n = 117, p = 0.0027), ADC_GSE8894 (n = 62, p = 0.01), and ADC_NCI (n = 282, p = 0.045)] and in four groups of stage I patients [ADC_CICAMS (n = 22, p = 0.017), ADC_PNAS (n = 76, p = 0.018), ADC_GSE13213 (n = 79, p = 0.02), and ADC_qPCR (n = 62, p = 0.006)]. In conclusion, by comparison of gene expression profiles during human lung developmental process and lung ADC progression, we revealed that the genes with a uniformly decreasing expression pattern during lung development are of enormous prognostic value for lung ADC.
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