The structural biology of patellamide biosynthesis.
The structural biology of patellamide biosynthesis.
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DOI：
10.1016/j.sbi.2014.10.006
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发表时间：
2014-12
影响因子：
6.8
通讯作者：
Naismith, James H.
中科院分区：
文献类型：
--
作者：
Koehnke, Jesko;Bent, Andrew F.;Houssen, Wael E.;Mann, Greg;Jaspars, Marcel;Naismith, James H.
近年来，结构生物学研究了甲苯酰胺及其相关天然产物的生物合成途径。这些途径产生的分子具有复杂的框架，并由于其中发现的氨基酸的多样性而显示出一系列不同的活动。由于这些分子很难用化学方法合成，因此对它们的性质的开发一直很有限。甲壳胺途径包括氨基酸的杂环化、多肽的裂解、多肽的大环化、杂环的氧化和异构化；密切相关的产物也被异丙基化。除了可能是自发的异构化外，所有这些转化的酶活性都已被确定。本文综述了近年来在氨基酸杂环、多肽裂解和多肽大环化等方面的结构和机理研究进展。这项工作应该有助于利用酶来生产能够利用其特性的天然产品的新型类似物。
The biosynthetic pathways for patellamide and related natural products have recently been studied by structural biology. These pathways produce molecules that have a complex framework and exhibit a diverse array of activity due to the variability of the amino acids that are found in them. As these molecules are difficult to synthesize chemically, exploitation of their properties has been modest. The patellamide pathway involves amino acid heterocyclization, peptide cleavage, peptide macrocyclization, heterocycle oxidation and epimerization; closely related products are also prenylated. Enzyme activities have been identified for all these transformations except epimerization, which may be spontaneous. This review highlights the recent structural and mechanistic work on amino acid heterocyclization, peptide cleavage and peptide macrocyclization. This work should help in using the enzymes to produce novel analogs of the natural products enabling an exploitation of their properties.
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影响因子：
16.8
作者：
Koehnke, Jesko;Bent, Andrew;Houssen, Wael E.;Zollman, David;Morawitz, Falk;Shirran, Sally;Vendome, Jeremie;Nneoyiegbe, Ada F.;Trembleau, Laurent;Botting, Catherine H.;Smith, Margaret C. M.;Jaspars, Marcel;Naismith, James H.
通讯作者：
Naismith, James H.
影响因子：
14.8
作者：
Donia, Mohamed S.;Hathaway, Brian J.;Schmidt, Eric W.
通讯作者：
Schmidt, Eric W.
DOI：
10.1107/s1744309113012931
发表时间：
2013-06
期刊：
Acta crystallographica. Section F, Structural biology and crystallization communications
影响因子：
--
作者：
Bent AF;Koehnke J;Houssen WE;Smith MC;Jaspars M;Naismith JH
通讯作者：
Naismith JH
影响因子：
15
作者：
McIntosh, John A.;Robertson, Charles R.;Schmidt, Eric W.
通讯作者：
Schmidt, Eric W.
影响因子：
14.8
作者：
Dunbar, Kyle L.;Melby, Joel O.;Mitchell, Douglas A.
通讯作者：
Mitchell, Douglas A.