The early repolarization pattern in the general population: clinical correlates and heritability.
The early repolarization pattern in the general population: clinical correlates and heritability.
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DOI：
10.1016/j.jacc.2011.04.003
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发表时间：
2011-05-31
影响因子：
24
通讯作者：
Huikuri, Heikki V.
中科院分区：
文献类型：
--
作者：
Noseworthy, Peter A.;Tikkanen, Jani T.;Porthan, Kimmo;Oikarinen, Lasse;Pietila, Arto;Harald, Kennet;Peloso, Gina M.;Merchant, Faisal M.;Jula, Antti;Vaananen, Heikki;Hwang, Shih-Jen;O'Donnell, Christopher J.;Salomaa, Veikko;Newton-Cheh, Christopher;Huikuri, Heikki V.
描述早期复极化模式（ERP）的临床相关性和遗传性在两个大型人群为基础的队列。越来越多的人认识到ERP与不良后果有关。弗雷明汉心脏研究（FHS, n = 3,995）和2000年健康调查（H2K, n = 5,489）的参与者包括在内。ERP被定义为在≥2个导联中j点升高≥0.1 mV，这些导联位于下（II、III、aVF）或侧（I、aVL、V4-6）区域或两者均有。我们测试了临床特征与ERP之间的关系，并估计了兄弟姐妹复发风险。FHS组243/3,955例（6.1%）和H2K组180/5,489例（3.3%）存在ERP。男性、年轻、较低的收缩压、较高的Sokolow-Lyon指数和较低的Cornell电压与ERP的存在独立相关。在FHS样本中，患有ERP个体的兄弟姐妹的ERP患病率为11.6%（复发风险比为1.89）。患有ERP的个体的兄弟姐妹发生ERP的未调整几率增加（OR 2.22, 95% CI 1.01-4.85, p = 0.047）。ERP与临床因素密切相关，在一般人群中有遗传基础的证据。进一步评估ERP的遗传决定因素是必要的。
To describe the clinical correlates and heritability of the early repolarization pattern (ERP) in two large population-based cohorts. There is growing recognition that ERP is associated with adverse outcomes. Participants of the Framingham Heart Study (FHS, n = 3,995) and the Health 2000 Survey (H2K, n = 5,489) were included. ERP was defined as J-point elevation ≥0.1 mV in ≥2 leads in either the inferior (II, III, aVF) or lateral (I, aVL, V4–6) territory or both. We tested the association between clinical characteristics and ERP and estimated sibling recurrence risk. ERP was present in 243/3,955 (6.1%) of FHS and 180/5,489 (3.3%) of H2K subjects. Male sex, younger age, lower systolic blood pressure, higher Sokolow-Lyon index, and lower Cornell voltage were independently associated with the presence of ERP. In the FHS sample, siblings of individuals with ERP had an ERP prevalence of 11.6% (recurrence risk ratio of 1.89). Siblings of individuals with ERP had an increased unadjusted odds of ERP (OR 2.22, 95% CI 1.01–4.85, p = 0.047). ERP shows strong association with clinical factors and has evidence for a heritable basis in general population. Further assessment of the genetic determinants of ERP is warranted.
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影响因子：
8.3
作者：
Okin, PM;Devereux, RB;Dahlöf, B
通讯作者：
Dahlöf, B
影响因子：
5.5
作者：
Burashnikov, Elena;Pfeiffer, Ryan;Barajas-Martinez, Hector;Delpon, Eva;Hu, Dan;Desai, Mayurika;Borggrefe, Martin;Haeissaguerre, Michel;Kanter, Ronald;Pollevick, Guido D.;Guerchicoff, Alejandra;Laino, Ruben;Marieb, Mark;Nademanee, Koonlawee;Nam, Gi-Byoung;Robles, Roberto;Schimpf, Rainer;Stapleton, Dwight D.;Viskin, Sami;Winters, Stephen;Wolpert, Christian;Zimmern, Samuel;Veltmann, Christian;Antzelevitch, Charles
通讯作者：
Antzelevitch, Charles
影响因子：
5.9
作者：
Klatsky, AL;Oehm, R;Armstrong, MA
通讯作者：
Armstrong, MA
影响因子：
15.8
作者：
Sinner MF;Reinhard W;Müller M;Beckmann BM;Martens E;Perz S;Pfeufer A;Winogradow J;Stark K;Meisinger C;Wichmann HE;Peters A;Riegger GA;Steinbeck G;Hengstenberg C;Kääb S
通讯作者：
Kääb S
DOI：
10.1111/j.1540-8167.2008.01326.x
发表时间：
2009-01-01
影响因子：
2.7
作者：
Haissaguerre, Michel;Chatel, Stephanie;Schott, Jean Jacques
通讯作者：
Schott, Jean Jacques