Phosphatidylethanol and alcohol consumption in reproductive age women.
Phosphatidylethanol and alcohol consumption in reproductive age women.
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DOI：
10.1111/j.1530-0277.2009.01113.x
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发表时间：
2010-03-01
期刊：
影响因子：
--
通讯作者：
Newman R
中科院分区：
文献类型：
--
作者：
Stewart SH;Law TL;Randall PK;Newman R
胎儿酒精障碍是可以预防的，但自我报告的饮酒可能会产生误导，并阻碍有效的治疗。生物标志物代表了评估酒精使用的另一种方法，这项研究在育龄妇女样本中评估了血液磷脂酰乙醇(Peth)和酒精使用之间的关系。通过有效的自我报告方法，对80名年龄在18岁至35岁之间的非怀孕女性的酒精使用情况进行了估计。PEH由一家签约实验室用液相色谱-串联质谱分析法进行测定。使用适合于PEH分布的回归方法来确定其与前两周饮酒的关系，并探讨饮酒模式对这种关系的影响。受试者工作特性分析被用来评估在95%特定界值下不同饮酒水平的PEH的敏感性。PEH与酒精摄入量呈线性正相关(p<；0.001)，在平均每天饮酒2杯或更多的受试者中，检测到PEH的比例为93%。在最近大量饮酒的女性中，总饮酒量与PEH之间的关系可能更强。不同个体之间的饮酒和PEH之间的关系差异很大，在高度特定的截止浓度下，对一定饮酒量的敏感度很低。PEH是育龄妇女中中度和重度饮酒的一个高度敏感的指标，当需要其他客观的酒精使用标志时，可以补充自我报告酒精筛查的使用。然而，为peth选择一个高度有效的截止浓度来区分不同水平的酒精消费可能是不可行的。
Fetal alcohol disorders are preventable, but self-reported alcohol consumption can be misleading and impede effective treatment. Biomarkers represent an alternative method for assessing alcohol use, and this study evaluated the relationship between blood phosphatidylethanol (PEth) and alcohol use in a sample of reproductive age women. Alcohol use was estimated by validated self-report methods in 80 non-pregnant women ages 18 to 35. PEth was measured by a contracted laboratory using a liquid chromatography-tandem mass spectrometry assay. Regression methods appropriate for the distribution of PEth were used to define its relationship to alcohol consumption during the prior 2 weeks and explore the effects of drinking patterns on this association. Receiver operating characteristic analysis was used to estimate the sensitivity of PEth for various drinking levels at 95% specific cutoffs. PEth had a positive linear association with grams of alcohol consumed (p<0.001), and was detectable in 93% of subjects consuming an average of 2 or more drinks per day. The relationship between total alcohol consumption and PEth may be stronger in women with recent heavy drinking days. The relationship between drinking and PEth varied considerably between individuals, and sensitivity for a certain amount of drinking was low at a highly specific cutoff concentration. PEth is a highly sensitive indicator of moderate and heavy alcohol consumption in reproductive age women and may complement the use of self-report alcohol screens when additional objective markers of alcohol use are desirable. However, choosing a highly valid cutoff concentration for PEth to differentiate various levels of alcohol consumption may not be feasible.
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影响因子：
3.5
作者：
Austin, PC;Escobar, M;Kopec, JA
通讯作者：
Kopec, JA
DOI：
10.1016/s0378-4347(97)00541-0
发表时间：
1998-02-13
期刊：
JOURNAL OF CHROMATOGRAPHY B
影响因子：
--
作者：
Gunnarsson, T;Karlsson, A;Odham, G
通讯作者：
Odham, G
影响因子：
2.9
作者：
Tolonen, A;Lehto, TM;Lehto, TM
通讯作者：
Lehto, TM
影响因子：
2.8
作者：
Wojcik, Mark H.;Hawthorne, Jeffrey S.
通讯作者：
Hawthorne, Jeffrey S.
DOI：
10.1097/01.alc.0000156082.08248.ab
发表时间：
2005-03-01
影响因子：
3.2
作者：
Wurst, FM;Alling, C;Litten, R
通讯作者：
Litten, R