Formal uniqueness in Ewald sphere corrected single particle analysis
Formal uniqueness in Ewald sphere corrected single particle analysis
复制标题
埃瓦尔德球校正单粒子分析的形式唯一性
DOI：
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Gustav Zickert
中科院分区：
文献类型：
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作者：
P. Kurlberg;Gustav Zickert
在单粒子分析（SPA）中，任务是从未知方向的结构的许多副本的低温电子显微镜图像中恢复大分子结构的散射势。理想化的，无噪声的SPA逆问题已被证明是唯一可解的-手-当正演模型是基于射线变换。更精确的正演模型考虑了埃瓦尔德球的非零曲率。我们分析了一个Ewald球校正的SPA正演模型，并利用衍射切片定理证明了相应的反问题是唯一可解的，包括手的结构。
In single particle analysis (SPA), the task is to recover the scattering potential of a macromolecular structure from cryo-electron microscope images of many copies of the structure in unknown orientations. The idealized, noise-free SPA inverse problem has been shown to be uniquely solvable — up to hand — when the forward model is based on the ray transform. More accurate forward models take the non-zero curvature of the Ewald sphere into account. We analyze an Ewald sphere corrected forward model for SPA and use the diffraction slice theorem to prove that the corresponding inverse problem is uniquely solvable, including the hand of the structure.
影响因子：
2.2
作者：
Wolf, M;DeRosier, DJ;Grigorieff, N
通讯作者：
Grigorieff, N