Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury.
Menopausal stage differences in endothelial resistance to ischemia-reperfusion injury.
复制标题
内皮抗缺血再灌注损伤的绝经阶段差异。
DOI：
10.14814/phy2.15768
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发表时间：
2023-09
影响因子：
2.5
通讯作者：
中科院分区：
文献类型：
--
作者：
在绝经后女性中，卵巢功能下降先于内皮功能障碍和内皮对缺血再灌注（IR）损伤的抵抗力减弱。我们假设IR损伤会降低内皮功能，绝经前妇女表现出最大的保护免受损伤，其次是早期，然后是晚期绝经后妇女。在绝经前（n = 11）、早期（n = 11;绝经后4 ± 1.6年）和晚期（n = 11;绝经后15 ± 5.5年）绝经后女性中，在基线和IR损伤后评估了血流介导的扩张（FMD）。基线FMD存在显著的组间差异（p = 0.007）;事后分析显示绝经前（7.8% ± 2.1%）和绝经后早期（7.1% ± 2.7%）之间的静息FMD相似，但绝经后晚期女性的FMD显著较低（4.5% ± 2.3%）。结果显示，IR损伤后FMD总体下降（p < 0.001），并且存在显著的条件 * 时间相互作用（p = 0.048），早期绝经后妇女表现出IR后FMD最显著的下降。我们的研究结果表明，健康的早期绝经后妇女对IR损伤的内皮抵抗力减弱。
In postmenopausal women, reduced ovarian function precedes endothelial dysfunction and attenuated endothelial resistance to ischemia‐reperfusion (IR) injury. We hypothesized that IR injury would lower endothelial function, with premenopausal women demonstrating the greatest protection from injury, followed by early, then late postmenopausal women. Flow‐mediated dilation (FMD) was assessed at baseline and following IR injury in premenopausal (n = 11), early (n = 11; 4 ± 1.6 years since menopause), and late (n = 11; 15 ± 5.5 years since menopause) postmenopausal women. There were significant group differences in baseline FMD (p = 0.007); post hoc analysis revealed a similar resting FMD between premenopausal (7.8% ± 2.1%) and early postmenopausal (7.1% ± 2.7%), but significantly lower FMD in late postmenopausal women (4.5% ± 2.3%). Results showed an overall decline in FMD after IR injury (p < 0.001), and a significant condition*time interaction (p = 0.048), with early postmenopausal women demonstrating the most significant decline in FMD following IR. Our findings indicate that endothelial resistance to IR injury is attenuated in healthy early postmenopausal women.
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