Membrane estradiol signaling in the brain.
Membrane estradiol signaling in the brain.
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DOI：
10.1016/j.yfrne.2009.04.011
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发表时间：
2009-08
影响因子：
7.4
通讯作者：
Dominguez, Reymundo
中科院分区：
文献类型：
--
作者：
Micevych, Paul;Dominguez, Reymundo
虽然神经系统中膜启动雌二醇信号传导的生理机制仍然难以捉摸，但在理解细胞信号传导的激活方面已经取得了很大进展。膜启动雌二醇信号传导激活G蛋白及其下游级联，但膜受体的身份和近端信号传导机制一直难以阐明。越来越多的证据表明，经典的细胞内雌激素受体-α (ERα)和ERβ被转运到膜上介导雌二醇细胞信号传导。此外，细胞膜ERα和ERβ与代谢性谷氨酸受体的相互作用已被确定，这解释了膜启动雌二醇信号的多形性作用。本文综述了膜雌二醇受体的作用机制，并讨论了支架蛋白和信号级联在中枢神经系统信号传导的重要组成部分神经黄体酮的合成和痛觉、性接受的调节中的作用。
While the physiology of membrane-initiated estradiol signaling in the nervous system has remained elusive, a great deal of progress has been made toward understanding the activation of cell signaling. Membrane-initiated estradiol signaling activates G proteins and their downstream cascades, but the identity of membrane receptors and the proximal signaling mechanism(s) have been more difficult to elucidate. Mounting evidence suggests that classical intracellular estrogen receptor-α (ERα) and ERβ are trafficked to the membrane to mediate estradiol cell signaling. Moreover, an interaction of membrane ERα and ERβ with metabotropic glutamate receptors has been identified that explains the pleomorphic actions of membrane-initiated estradiol signaling. This review focuses on the mechanism of actions initiated by membrane estradiol receptors and discusses the role of scaffold proteins and signaling cascades involved in the regulation of nociception, sexual receptivity and the synthesis of neuroprogesterone, an important component in the central nervous system signaling.
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DOI：
10.1073/pnas.91.18.8517
发表时间：
1994-08-30
影响因子：
11.1
作者：
ARONICA, SM;KRAUS, WL;KATZENELLENBOGEN, BS
通讯作者：
KATZENELLENBOGEN, BS
影响因子：
4.8
作者：
Belcher, SM;Le, HH;Wong, JK
通讯作者：
Wong, JK
影响因子：
4.8
作者：
Bale, TL;Dorsa, DM
通讯作者：
Dorsa, DM
影响因子：
3.3
作者：
Acconcia, F;Ascenzi, P;Marino, M
通讯作者：
Marino, M
影响因子：
2.5
作者：
Aloisi, AM;Ceccarelli, I;Herdegen, T
通讯作者：
Herdegen, T