Characteristic Cytological Findings of Lobular Endocervical Glandular Hyperplasia Associated with Adenocarcinoma of the Uterine Cervix
Characteristic Cytological Findings of Lobular Endocervical Glandular Hyperplasia Associated with Adenocarcinoma of the Uterine Cervix
复制标题
与子宫颈腺癌相关的小叶子宫颈内腺增生的特征性细胞学表现
DOI：
10.1159/000509667
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发表时间：
2020
期刊：
影响因子：
1.8
通讯作者：
Takazawa Yutaka
中科院分区：
文献类型：
--
作者：
Ishii Shuhei;Ito Takahiko;Yamada Marisa;Yamazaki Naoko;Ikebata Koichi;Fujiyama Junzo;Furuta Noriyuki;Komatsu Kyoko;Takeuchi Kengo;Sugiyama Yuko;Takazawa Yutaka
目的探讨小叶型颈内腺增生症(LEGH)合并腺癌的细胞学表现，并结合组织化学和免疫组织化学方法明确LEGH并存腺癌的特点。方法对18例LEGH手术病例进行回顾性分析，分为单纯型(单纯型)、不典型(非典型型)和LEGH并腺癌(混合型)3组。混合型定义为Legh或不典型Legh伴原位或浸润性腺癌。对常规宫颈涂片(巴氏染色)细胞学检查结果进行分析。结果单纯型(7例)的细胞学特征为腺细胞团，多呈单层片状，小核均匀，粘蛋白呈金黄色；非典型型(5例)和混合型(6例)的腺细胞团与纯型腺细胞团相似，但腺体结构复杂，粘蛋白定位于腺细胞团表面。Ki-67标记指数在非典型型和混合型明显高于单纯型。6例混合型中2例为胃型粘液癌(MC-G)。结论LEGH与腺癌类型无关。复杂的腺体结构或粘蛋白定位于腺体细胞簇表面，可能是诊断不典型和混合型LEGH的有用细胞学表现。
ObjectiveTo investigate the cytological findings of lobular endocervical glandular hyperplasia (LEGH) associated with adenocarcinoma and to clarify its characteristics and the coexisting adenocarcinoma using histochemistry and immunohistochemistry.MethodsEighteen surgical cases of LEGH of the uterine cervix were retrospectively reviewed and classified into 3 groups: pure (pure type), atypical (atypical type), and LEGH with adenocarcinoma (mixed type). The mixed type is defined as LEGH or atypical LEGH with in situ or invasive adenocarcinoma. Cytological findings of conventional endocervical smear specimens (Papanicolaou stain) were analyzed. Histochemistry (periodic acid-Schiff reaction) and immunohistochemistry (M-GGMC-1, Muc-6 glycoprotein, and Ki-67) were performed using tissue specimens.ResultsCytologically, the pure type (7 cases) is characterized by glandular cell clusters that tended to form monolayered sheets with uniformly small nuclei and contain golden-yellowish mucin, whereas atypical (5 cases) and mixed (6 cases) types are characterized by glandular cell clusters similar to those of the pure type, but with complex glandular structures and mucin localization on the surface of glandular cell clusters. Ki-67 labeling index was significantly higher in atypical and mixed types than that in the pure type. Gastric-type mucinous carcinoma (MC-G) was observed in 2 out of 6 cases with mixed type.ConclusionsLEGH is found to be associated with adenocarcinoma types other than MC-G. Complex glandular structures or mucin localization on the surface of glandular cell clusters may be useful cytological findings to detect atypical and mixed types of LEGH.
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影响因子：
6.4
作者：
Mikami, Y;Hata, S;Manabe, T
通讯作者：
Manabe, T
影响因子：
1.3
作者：
Hashi, Akihiko;Yuminamochi, Tsutomu;Hoshi, Kazuhiko
通讯作者：
Hoshi, Kazuhiko
小叶状宫颈管腺增生、恶性腺瘤和常见宫颈腺癌中性粘蛋白胞浆定位模式的差异
影响因子：
3.5
作者：
I. Hayashi;H. Tsuda;T. Shimoda;Arafumi Maeshima;T. Kasamatsu;Takuro Yamada;R. Tsunematsu
通讯作者：
R. Tsunematsu
Ohishi Y 等人：“人原发性卵巢癌中的 ATP 结合盒超家族转运蛋白基因表达”，Clin Cancer Res，第 8 卷，3767-3775 (2002)。
DOI：
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发表时间：
--
期刊：
影响因子：
--
作者：
通讯作者：
--
影响因子：
1.3
作者：
Hata, S;Mikami, Y;Manabe, T
通讯作者：
Manabe, T