Sniff adjustment in an odor discrimination task in the rat: analytical or synthetic strategy?
Sniff adjustment in an odor discrimination task in the rat: analytical or synthetic strategy?
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DOI：
10.3389/fnbeh.2014.00145
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发表时间：
2014
影响因子：
3
通讯作者：
Buonviso N
中科院分区：
文献类型：
--
作者：
Courtiol E;Lefèvre L;Garcia S;Thévenet M;Messaoudi B;Buonviso N
越来越多的证据表明，嗅闻不仅是气味分子的传递方式，而且有助于嗅觉感知。然而，嗅探变化的确切作用仍然未知。分区假说表明，动物使用嗅的变化，以优化气味分子的沉积在嗅觉上皮（OE）的最受欢迎的地区。因此，嗅闻取决于气味物质的物理化学性质，特别是它们的吸附作用。Rojas-Líbano和Kay测试了这一假设，并表明当大鼠必须在二元混合物中靶向高吸附（HS）分子或低吸附（LS）分子时，它们使用不同的嗅探策略。当老鼠面对两种相似的气味吸附剂时，它们使用哪种嗅闻策略仍然没有答案。特别地，是根据其吸附特性（分析处理）独立地针对每种气味剂调整嗅闻，还是基于配对上下文（合成处理）调整嗅闻？我们测试了这些假设的大鼠进行两个选择歧视的气味具有相似的吸附性能。在行为任务中，我们使用全身体积描记法以非侵入性的方式记录了嗅闻。我们发现，嗅闻的变化不仅是一个问题的气味吸附性能和相同的气味不同，这取决于气味对，它是呈现。这些结果表明，而不是被调整分析，嗅探，而不是综合调整，并取决于对气味的歧视任务。我们的研究结果表明，嗅闻是一种特定的感觉运动行为，依赖于复杂的合成过程。
A growing body of evidence suggests that sniffing is not only the mode of delivery for odorant molecules but also contributes to olfactory perception. However, the precise role of sniffing variations remains unknown. The zonation hypothesis suggests that animals use sniffing variations to optimize the deposition of odorant molecules on the most receptive areas of the olfactory epithelium (OE). Sniffing would thus depend on the physicochemical properties of odorants, particularly their sorption. Rojas-Líbano and Kay tested this hypothesis and showed that rats used different sniff strategies when they had to target a high-sorption (HS) molecule or a low-sorption (LS) molecule in a binary mixture. Which sniffing strategy is used by rats when they are confronted to discrimination between two similarly sorbent odorants remains unanswered. Particularly, is sniffing adjusted independently for each odorant according to its sorption properties (analytical processing), or is sniffing adjusted based on the pairing context (synthetic processing)? We tested these hypotheses on rats performing a two-alternative choice discrimination of odorants with similar sorption properties. We recorded sniffing in a non-invasive manner using whole-body plethysmography during the behavioral task. We found that sniffing variations were not only a matter of odorant sorption properties and that the same odorant was sniffed differently depending on the odor pair in which it was presented. These results suggest that rather than being adjusted analytically, sniffing is instead adjusted synthetically and depends on the pair of odorants presented during the discrimination task. Our results show that sniffing is a specific sensorimotor act that depends on complex synthetic processes.
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DOI：
10.1523/jneurosci.4101-12.2013
发表时间：
2013-01-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cenier T;McGann JP;Tsuno Y;Verhagen JV;Wachowiak M
通讯作者：
Wachowiak M
影响因子：
2.5
作者：
Courtiol, Emmanuelle;Hegoburu, Chloe;Buonviso, Nathalie
通讯作者：
Buonviso, Nathalie
影响因子：
5.3
作者：
Scott, John W.;Sherrill, Lisa;Zhao, Kai
通讯作者：
Zhao, Kai
影响因子：
2.9
作者：
CLARKE, S;TROWILL, JA
通讯作者：
TROWILL, JA
影响因子：
3.5
作者：
Garcia S;Fourcaud-Trocmé N
通讯作者：
Fourcaud-Trocmé N