Functional and structural correlates of memory in patients with mesial temporal lobe epilepsy.
Functional and structural correlates of memory in patients with mesial temporal lobe epilepsy.
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中颞叶癫痫患者的记忆功能和结构相关。
DOI：
10.3389/fneur.2015.00103
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发表时间：
2015
影响因子：
3.4
通讯作者：
McAndrews MP
中科院分区：
文献类型：
--
作者：
Barnett AJ;Park MT;Pipitone J;Chakravarty MM;McAndrews MP
内侧颞叶癫痫（mTLE）患者通常表现出材料特异性记忆障碍（左半球为语言，右半球为视觉空间），在针对内侧和前外侧颞叶皮层的致痫区域进行手术后可能会加剧。越来越多的证据表明，使用MRI表征这些区域的结构和功能完整性可以帮助预测术后记忆进一步下降的风险。我们在一组26名单侧mTLE患者中研究了海马完整性的结构和功能指数与术前记忆表现之间关系的性质。结构完整性评估使用海马体积，而功能完整性评估使用海马激活过程中的编码新的场景。我们根据不对称性量化了结构和功能的完整性，计算为（L-R）/（L + R）。从临床数据库中计算语言和视觉记忆的因子评分，并使用不对称评分（语言-视觉）来表征记忆性能。我们发现，正如预期的那样，左和右mTLE（RTLE）组之间的海马体积不对称性有显着差异，每组均显示出有利于未受影响的颞叶的不对称性。编码激活不对称性显示了类似的模式，左mTLE患者显示激活优先于右半球和RTLE患者显示相反。最后，我们证明了功能完整性介导了记忆不对称的结构完整性和记忆性能之间的关系，这表明即使结构变化是明显的，最终也是组织的功能完整性最能解释行为性能。
Individuals with medial temporal lobe epilepsy (mTLE) often show material-specific memory impairment (verbal for left, visuospatial for right hemisphere), which can be exacerbated following surgery aimed at the epileptogenic regions of medial and anterolateral temporal cortex. There is a growing body of evidence suggesting that characterization of structural and functional integrity of these regions using MRI can aid in prediction of post-surgical risk of further memory decline. We investigated the nature of the relationship between structural and functional indices of hippocampal integrity with pre-operative memory performance in a group of 26 patients with unilateral mTLE. Structural integrity was assessed using hippocampal volumes, while functional integrity was assessed using hippocampal activation during the encoding of novel scenes. We quantified structural and functional integrity in terms of asymmetry, calculated as (L − R)/(L + R). Factor scores for verbal and visual memory were calculated from a clinical database and an asymmetry score (verbal − visual) was used to characterize memory performance. We found, as expected, a significant difference between left and right mTLE (RTLE) groups for hippocampal volume asymmetry, with each group showing an asymmetry favoring the unaffected temporal lobe. Encoding activation asymmetry showed a similar pattern, with left mTLE patients showing activation preferential to the right hemisphere and RTLE patients showing the reverse. Finally, we demonstrated that functional integrity mediated the relationship between structural integrity and memory performance for memory asymmetry, suggesting that even if structural changes are evident, ultimately it is the functional integrity of the tissue that most closely explains behavioral performance.
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影响因子：
5.6
作者：
Martin, RC;Sawrie, SM;Kuzniecky, R
通讯作者：
Kuzniecky, R
影响因子：
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通讯作者：
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通讯作者：
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作者：
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通讯作者：
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