Prognostic role of CD133 expression in colorectal cancer: a meta-analysis.
Prognostic role of CD133 expression in colorectal cancer: a meta-analysis.
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CD133 表达在结直肠癌中的预后作用：荟萃分析
DOI：
10.1186/1471-2407-12-573
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发表时间：
2012-12-05
期刊：
影响因子：
3.8
通讯作者：
Huang J
中科院分区：
文献类型：
--
作者：
Wang K;Xu J;Zhang J;Huang J
CD133被认为是结直肠癌(CRC)中一种可能的肿瘤干细胞标记物。然而，CD133在结直肠癌中的临床和预后意义仍存在争议。方法选择截至2012年10月评估CD133在结直肠癌中的临床或预后意义的文献。结果共有12篇研究符合纳入标准，共纳入3652例病例。CD133与结直肠癌的侵袭深度(OR=1.44，95%可信区间：0.77~2.68，Z=1.15，P=0.252)和肿瘤分化程度(OR=0.63，95%CI：0.28~1.46，Z=−1.06，P=0.286)无关。CD133与淋巴结转移(OR=1.16，95%CI：0.87~1.54，Z=1.05，P=0.315)和淋巴侵犯(OR=1.08，95%CI：0.81~1.43，Z=0.53，P=0.594)无统计学意义。结论CD133的过度表达可能在结直肠癌的发生发展中起重要作用，而CD133的过度表达与患者的生存状况密切相关。如果这些发现被精心设计的前瞻性研究证实，CD133可能是一个有用的临床应用标记物。
BackgroundCD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial.MethodsPublications were identified which assessed the clinical or prognostic significance of CD133 in CRC up to October 2012. A meta-analysis was performed to clarify the association between CD133 expression and clinical outcomes.ResultsA total of 12 studies met the inclusion criteria, and comprised 3652 cases. Analysis of these data showed that CD133 was not significantly associated with the depth of CRC invasion (odds ratio [OR] = 1.44, 95% confidence interval [CI]: 0.77–2.68, Z = 1.15,P= 0.252) or tumor differentiation (OR = 0.63, 95% CI: 0.28–1.46, Z = −1.06,P= 0.286). Also, there was no statistically significant association of CD133 with lymph node metastasis (OR = 1.16, 95% CI: 0.87–1.54, Z = 1.05,P= 0.315) or lymphatic invasion (OR = 1.08, 95% CI: 0.81–1.43, Z = 0.53,P= 0.594). However, in identified studies, overexpression of CD133 was highly correlated with reduced overall survival (relative risk [RR] = 2.14, 95% CI: 1.45–3.17, Z = 3.81,P= 0.0001).ConclusionsCD133 may play an important role in the progression of CRC, and overexpression of CD133 is closely related with poorer patient survival. If these findings are confirmed by well-designed prospective studies, CD133 may be a useful maker for clinical applications.
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