Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia.
Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia.
复制标题
DOI：
10.1016/j.ebiom.2016.09.008
复制
发表时间：
2016-10
期刊：
影响因子：
11.1
通讯作者：
Ueno T
中科院分区：
文献类型：
--
作者：
Kuga H;Onitsuka T;Hirano Y;Nakamura I;Oribe N;Mizuhara H;Kanai R;Kanba S;Ueno T
最近的MRI研究表明，精神分裂症的特征是脑灰质减少，这在疾病的急性状态下进展。在精神分裂症患者中也有报道，伽马振荡中的皮质回路异常，例如对伽马频率（> 30 Hz）刺激的听觉稳态反应（ASSR）缺陷。在目前的研究中，我们研究了在点击刺激BOLD信号的神经反应。我们从15名急性发作精神分裂症（AESZ）患者、14名症状严重程度匹配的非急性发作精神分裂症（NASZ）患者和24名健康对照（HC）中获得了20、30、40和80 Hz频率的点击序列引起的BOLD反应，通过标准的一般线性模型进行评估基于分析。与HC和NASZ组相比，AESZ组左侧听觉皮层对80 Hz刺激的ASSR-BOLD信号显著增加。此外，增强的80 Hz ASSR-BOLD信号与AESZ参与者更严重的幻听体验相关。目前的研究结果表明，神经过度激活发生在80 Hz听觉刺激的左侧听觉皮层急性状态精神分裂症患者。鉴于异常γ活动和谷氨酸水平升高之间可能存在关联，我们的数据可能反映了精神分裂症急性状态下听觉皮层中的谷氨酸毒性，这可能导致左侧颞横回的进行性变化。我们研究了BOLD信号在点击刺激过程中的神经反应。我们评估了急性和非急性精神分裂症患者以及健康对照组。80 Hz听觉刺激激活急性精神分裂症患者的左侧听觉皮层。我们的数据可能反映了急性精神分裂症的左听觉皮层谷氨酸毒性。最近的MRI研究表明，精神分裂症的特点是大脑灰质减少，在疾病的急性状态下恶化。周期性的听觉短声序列引起听觉稳态反应（ASSR），精神分裂症中有ASSR异常的报道。我们使用BOLD信号研究了点击刺激期间的神经反应，这可能反映了谷氨酸毒性。与非急性期精神分裂症患者和健康对照组相比，急性期精神分裂症患者在左侧听觉皮层对80 Hz刺激的ASSR-BOLD显著增加。我们的数据表明，在急性状态精神分裂症的BOLD模式，这可能反映了谷氨酸中毒在精神分裂症的急性期在左上级颞叶皮层进行性体积减少神经元的过度激活。
Recent MRI studies have shown that schizophrenia is characterized by reductions in brain gray matter, which progress in the acute state of the disease. Cortical circuitry abnormalities in gamma oscillations, such as deficits in the auditory steady state response (ASSR) to gamma frequency (> 30-Hz) stimulation, have also been reported in schizophrenia patients. In the current study, we investigated neural responses during click stimulation by BOLD signals. We acquired BOLD responses elicited by click trains of 20, 30, 40 and 80-Hz frequencies from 15 patients with acute episode schizophrenia (AESZ), 14 symptom-severity-matched patients with non-acute episode schizophrenia (NASZ), and 24 healthy controls (HC), assessed via a standard general linear-model-based analysis. The AESZ group showed significantly increased ASSR-BOLD signals to 80-Hz stimuli in the left auditory cortex compared with the HC and NASZ groups. In addition, enhanced 80-Hz ASSR-BOLD signals were associated with more severe auditory hallucination experiences in AESZ participants. The present results indicate that neural over activation occurs during 80-Hz auditory stimulation of the left auditory cortex in individuals with acute state schizophrenia. Given the possible association between abnormal gamma activity and increased glutamate levels, our data may reflect glutamate toxicity in the auditory cortex in the acute state of schizophrenia, which might lead to progressive changes in the left transverse temporal gyrus. We investigated neural responses during click stimulation by BOLD signals. We evaluated patients with acute and non-acute schizophrenia, and healthy controls. 80-Hz auditory stimulation activated the left auditory cortex in acute schizophrenia. Our data may reflect left auditory cortex glutamate toxicity in acute schizophrenia. Recent MRI studies show that schizophrenia is characterized by reduced brain gray matter, which deteriorates in the acute state of the disease. Periodic auditory click trains elicit auditory steady-state responses (ASSRs), and ASSR abnormalities are reported in schizophrenia. We investigated neural responses during click stimulation using BOLD signals, which may reflect glutamate toxicity. Compared with non-acute schizophrenia patients and healthy controls, acute episode schizophrenia patients showed significantly increased ASSR-BOLD to 80-Hz stimuli in the left auditory cortex. Our data demonstrate neuronal over activation in terms of the BOLD pattern in acute state schizophrenia, which might reflect progressive volume reduction in the left superior temporal cortex by glutamate toxicity during the acute phase of schizophrenia.
登录
查看更多内容
影响因子：
25.8
作者：
Hirano Y;Oribe N;Kanba S;Onitsuka T;Nestor PG;Spencer KM
通讯作者：
Spencer KM
影响因子：
9.2
作者：
Goense, Jozien B. M.;Logothetis, Nikos K.
通讯作者：
Logothetis, Nikos K.
影响因子：
2.5
作者：
Murayama, Yusuke;Biessmann, Felix;Logothetis, Nikos K.
通讯作者：
Logothetis, Nikos K.
影响因子：
6.6
作者：
Marsman, Anouk;van den Heuvel, Martijn P.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff
影响因子：
56.9
作者：
Niessing, J;Ebisch, B;Galuske, RAW
通讯作者：
Galuske, RAW