Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis.
Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis.
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DOI：
10.1080/03014460.2020.1727011
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发表时间：
2020-03
影响因子：
1.7
通讯作者：
Baker JL
中科院分区：
文献类型：
--
作者：
Aarestrup J;Jensen BW;Ulrich LG;Hartwell D;Trabert B;Baker JL
成年时的体型可能与子宫内膜异位症和子宫腺肌症的风险有关，但对其与早年的体型之间的关系知之甚少。检查出生体重、儿童体重指数(BMI)和身高是否与子宫内膜异位症和子宫腺肌症的风险有关。来自哥本哈根学校健康记录的171,362名出生于1930-1996年的女孩被包括在内，她们的体重和身高都在7-13岁之间。结果是从健康登记处获得的。用COX回归估计危险比(HR)和95%可信区间(CI)。随访期间，共诊断子宫内膜异位症2149例，子宫腺肌症1410例。儿童BMI与子宫内膜异位症呈负相关(7岁时每z分数HR=0.92[95%CI：0.88-0.96])。相反，童年身高与子宫内膜异位症呈正相关(7岁时每z分数HR=1.09[95%CI：1.05-1.14])。子宫内膜异位症的部位与儿童身体大小的关系没有差别。儿童期BMI和身高与子宫腺肌病无关。出生体重与子宫内膜异位症或子宫腺肌症无关。身材苗条的女孩更容易被诊断为子宫内膜异位症，而不是子宫腺肌症。这些发现表明，子宫内膜异位症风险的指标在早期就已经很明显了。
Body size in adult life is likely associated with risks of endometriosis and adenomyosis, yet little is known about associations with body size earlier in life. To examine whether birth weight, childhood body mass index (BMI), and height are associated with risks of endometriosis and adenomyosis. From the Copenhagen School Health Records Register 171,362 girls, born 1930–1996, with measured weights and heights at ages 7–13 were included. Outcomes were obtained from health registers. Cox regressions were performed to estimate hazard ratios (HR) and 95% confidence intervals (CI). During follow-up, 2149 endometriosis cases and 1410 adenomyosis cases were diagnosed. Childhood BMI was inversely associated with endometriosis (HR=0.92 [95% CI: 0.88–0.96] per z-score at age 7). In contrast, childhood height was positively associated with endometriosis (HR=1.09 [95% CI: 1.05–1.14] per z-score at age 7). Associations with childhood body size did not differ by endometriosis location. Childhood BMI and height were not associated with adenomyosis. Birth weight was not associated with endometriosis or adenomyosis. Lean and tall girls are more often diagnosed with endometriosis, but not adenomyosis. These findings suggest that indicators of endometriosis risk are already apparent at early ages.
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影响因子：
2
作者：
COLE, TJ;GREEN, PJ
通讯作者：
GREEN, PJ
影响因子：
1.7
作者：
Angell-Andersen, E;Tretli, S;Grotmol, T
通讯作者：
Grotmol, T
影响因子：
8.8
作者：
Kim, H. S.;Kim, T. H.;Chung, H. H.;Song, Y. S.
通讯作者：
Song, Y. S.
影响因子：
6.1
作者：
Farland, L. V.;Missmer, S. A.;Kvaskoff, M.
通讯作者：
Kvaskoff, M.
影响因子：
2.9
作者：
Jensen CB;Gamborg M;Heitmann B;Sørensen TI;Baker JL
通讯作者：
Baker JL