Induction of the chick columella and its integration with the inner ear
Induction of the chick columella and its integration with the inner ear
复制标题
雏鸡小柱的诱导及其与内耳的融合
DOI：
10.1002/dvdy.23788
复制
发表时间：
2012
影响因子：
2.5
通讯作者：
R. Ladher
中科院分区：
文献类型：
--
作者：
Y. Zou;Siu‐Shan Mak;Hui;Dong‐yi Han;Hongchang Zhuang;Shi;R. Ladher
背景资料：小鸡的听觉复合体和人类一样，是由内耳、中耳和外耳之间紧密而高度有序的连接组成的。与哺乳动物不同，鸡的中耳只有一个小骨，称为鼻小柱。这两个独立的谱系表明，一定存在某种机制，确保内耳和鼻小柱之间的连接;然而，整合的基础尚不清楚。结果：使用鹌鹑-小鸡嵌合体，我们证明了小柱发育取决于信号相互作用。具体而言，咽内胚层和颅轴旁中胚层都可以改变鼻小柱的形态。只有一个离散的区域的咽内胚层发挥这种图案化的活动，这一地区是指定的覆盖近轴中胚层。结论：近轴中胚层也被用于内耳的诱导，因此我们建议，这种重叠源的信号线索在中耳和内耳的发展可能是这些结构的整合。Developmental Dynamics 241：1104-1110，2012.© 2012 Wiley Periodicals，Inc.
Background: The auditory complex of the chick, like that of humans, is made of intimate and highly ordered connections between the inner ear, the middle ear, and the outer ear. Unlike mammals, the middle ear of chick has only one ossicle, known as the columella. The independent lineages of the two suggest that some mechanism must exist that ensures the connectivity between the inner ear and the columella; however, the basis of integration is not known. Results: Using quail‐chick chimeras, we demonstrate that columella development depends on signaling interactions. Specifically, both pharyngeal endoderm and cranial paraxial mesoderm can alter the morphology of the columella. Only a discrete region of pharyngeal endoderm exerts this patterning activity, and this region is specified by the overlying paraxial mesoderm. Conclusions: Paraxial mesoderm is also used in the induction of the inner ear, thus we propose that this overlapping source of signalling cues in both middle and inner ear development may underlie the integration of these structures. Developmental Dynamics 241:1104–1110, 2012. © 2012 Wiley Periodicals, Inc.
DOI：
10.1002/bdrc.20007
发表时间：
2004-06-01
期刊：
Birth defects research. Part C, Embryo today : reviews
影响因子：
--
作者：
Clouthier, David E;Schilling, Thomas F
通讯作者：
Schilling, Thomas F
DOI：
10.1016/0300-9629(93)90030-8
发表时间：
1993
期刊：
Comparative biochemistry and physiology. Comparative physiology
影响因子：
--
作者：
Saunders,JC;Doan,DE;Cohen,YE
通讯作者：
Cohen,YE