N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition.
N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition.
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DOI：
10.1254/jphs.12075fp
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发表时间：
2012
影响因子：
3.5
通讯作者：
Nishiyama A
中科院分区：
文献类型：
--
作者：
Lei B;Nakano D;Fujisawa Y;Liu Y;Hitomi H;Kobori H;Mori H;Masaki T;Asanuma K;Tomino Y;Nishiyama A
我们最近证实，L/N型钙通道阻滞剂西尼地平对肾小球足细胞损伤具有保护作用，尤其是对表达N型钙通道(N-CC)的肥胖高血压大鼠。由于N-CC表达于交感神经末梢，我们评价了西尼地平对神经支配和去神经支配的自发性高血压大鼠(SHR)的肾脏保护作用。雄性SHR行单侧肾切除，饲喂4%高盐饲料(HS-UNX-SHR)。实验动物于9~27周龄随机分为4组，每组15只，每组15只，每组15只。每组10只，每组10只。去肾神经可减轻HS-UNX-SHR血压升高，但不能抑制尿蛋白排泄和足细胞损伤。与赋形剂治疗的HS-UNX-SHR相比，经神经支配和失神经支配的HS-UNX-SHR的西尼地平同样产生显著的降压作用，并抑制尿蛋白排泄和足细胞损伤。提示肾神经在西尼地平对HS-UNX-SHR的肾脏保护作用中所起的作用有限。
We recently demonstrated that cilnidipine, an L/N-type calcium channel blocker, elicits protective effects against glomerular podocyte injury, in particular, in obese hypertensive rats that express the N-type calcium channel (N-CC). Since the N-CC is known to be expressed in sympathetic nerve endings, we evaluated the reno-protective effects of cilnidipine in innervated and denervated spontaneously hypertensive rats (SHR). Male SHR were uninephrectomized and fed 4% high-salt diet (HS-UNX-SHR). Animals were divided into groups, as follows, and observed from 9 to 27 weeks of age: 1) vehicle (n = 14), 2) vehicle plus renal-denervation (n = 15), 3) cilnidipine (50 mg/kg per day, p.o.; n = 10), and 4) cilnidipine plus renal-denervation (n = 15). Renal denervation attenuated elevations in blood pressure, but failed to suppress urinary protein excretion and podocyte injury in HS-UNX-SHR. Cilnidipine in both innervated and denervated HS-UNX-SHR similarly induced significant antihypertensive effects, as well as suppressing the urinary protein excretion and podocyte injury, compared to vehicle-treated HS-UNX-SHR. These data indicate that renal nerves have a limited contribution to the cilnidipine-induced reno-protective effects in HS-UNX-SHR.
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影响因子：
5
作者：
Fujii, T;Kurata, H;Matsumura, Y
通讯作者：
Matsumura, Y
影响因子：
4.9
作者：
Fan, Yu-Yan;Kohno, Masakazu;Nishiyama, Akira
通讯作者：
Nishiyama, Akira
影响因子：
4.9
作者：
Golin, R;Pieruzzi, F;Zanchetti, A
通讯作者：
Zanchetti, A
影响因子：
3.5
作者：
Lei B;Hitomi H;Mori T;Nagai Y;Deguchi K;Mori H;Masaki T;Nakano D;Kobori H;Kitaura Y;Nishiyama A
通讯作者：
Nishiyama A
影响因子：
4.9
作者：
Cao, Wei;Zhou, Qiu G.;Hou, Fan F.
通讯作者：
Hou, Fan F.