Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons.
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DOI：
10.1038/nn.3404
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发表时间：
2013-07
影响因子：
25
通讯作者：
Woolf, Clifford J.
中科院分区：
文献类型：
--
作者：
Roberson, David P.;Gudes, Sagi;Sprague, Jared M.;Patoski, Haley A. W.;Robson, Victoria K.;Blasl, Felix;Duan, Bo;Oh, Seog Bae;Bean, Bruce P.;Ma, Qiufu;Binshtok, Alexander M.;Woolf, Clifford J.
The peripheral terminals of primary sensory neurons detect histamine and non-histamine itch-provoking ligands through molecularly distinct transduction mechanisms. It remains unclear, however, whether these distinct pruritogens activate the same or different afferent fibers. We utilized a strategy of reversibly silencing specific subsets of murine pruritogen-sensitive sensory axons by targeted delivery of a charged sodium-channel blocker and found that functional blockade of histamine itch did not affect the itch evoked by chloroquine or SLIGRL-NH2, and vice versa. Notably, blocking itch-generating fibers did not reduce pain-associated behavior. However, silencing TRPV1+ or TRPA1+ neurons allowed AITC or capsaicin respectively to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch. These findings support the presence of functionally distinct sets of itch-generating neurons and suggest that targeted silencing of activated sensory fibers may represent a clinically useful anti-pruritic therapeutic approach for histaminergic and non-histaminergic pruritus.
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影响因子：
8.8
作者：
Binshtok AM;Gerner P;Oh SB;Puopolo M;Suzuki S;Roberson DP;Herbert T;Wang CF;Kim D;Chung G;Mitani AA;Wang GK;Bean BP;Woolf CJ
通讯作者：
Woolf CJ
影响因子：
7.4
作者：
Kim HY;Kim K;Li HY;Chung G;Park CK;Kim JS;Jung SJ;Lee MK;Ahn DK;Hwang SJ;Kang Y;Binshtok AM;Bean BP;Woolf CJ;Oh SB
通讯作者：
Oh SB
DOI：
10.1523/jneurosci.3509-12.2012
发表时间：
2012-10-17
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Liu Q;Sikand P;Ma C;Tang Z;Han L;Li Z;Sun S;LaMotte RH;Dong X
通讯作者：
Dong X
影响因子：
3
作者：
Khalil, Insaf F.;Alifrangis, Michael;Koch, Claus
通讯作者：
Koch, Claus
影响因子：
25
作者：
Han, Liang;Ma, Chao;Liu, Qin;Weng, Hao-Jui;Cui, Yiyuan;Tang, Zongxiang;Kim, Yushin;Nie, Hong;Qu, Lintao;Patel, Kush N.;Li, Zhe;McNeil, Benjamin;He, Shaoqiu;Guan, Yun;Xiao, Bo;LaMotte, Robert H.;Dong, Xinzhong
通讯作者：
Dong, Xinzhong