Molecular response assessment using circulating tumor DNA (ctDNA) in advanced solid tumors.
Molecular response assessment using circulating tumor DNA (ctDNA) in advanced solid tumors.
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DOI：
10.1038/s41416-023-02445-1
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发表时间：
2023-12
影响因子：
8.8
通讯作者：
Aggarwal, Charu
中科院分区：
文献类型：
--
作者：
Thompson, Jeffrey C.;Scholes, Dylan G.;Carpenter, Erica L.;Aggarwal, Charu
过去二十年来，晚期恶性肿瘤患者的治疗格局发生了巨大变化。越来越多的靶向治疗和免疫治疗选择提高了部分患者的缓解率和生存率，但确定哪些患者将从这些治疗中获得临床获益，以避免潜在的毒性并降低医疗成本仍然是一个临床挑战。无细胞循环肿瘤 DNA (ctDNA) 由肿瘤细胞释放到体循环中，并且已经成为晚期非小细胞肺癌及其他恶性肿瘤的非侵入性肿瘤基因分型常规临床实践中不可或缺的一部分。 ctDNA 的半衰期短，为利用 ctDNA 的早期治疗变化来实时评估治疗反应和结果（称为分子反应）提供了独特的机会。在这里，我们对分子反应在晚期癌症患者预后预测中的应用进行了总结和回顾，包括当前的科学状况、其在临床中的应用以及开发这种预测工具的后续步骤。
The therapeutic landscape for patients with advanced malignancies has changed dramatically over the last twenty years. The growing number of targeted therapies and immunotherapeutic options available have improved response rates and survival for a subset of patients, however determining which patients will experience clinical benefit from these therapies in order to avoid potential toxicities and reduce healthcare costs remains a clinical challenge. Cell-free circulating tumor DNA (ctDNA) is shed by tumor cells into systemic circulation and is already an integral part of routine clinical practice for the non-invasive tumor genotyping in advanced non-small cell lung cancer as well as other malignancies. The short half-life of ctDNA offers a unique opportunity to utilize early on-treatment changes in ctDNA for real-time assessment of therapeutic response and outcome, termed molecular response. Here, we provide a summary and review of the use of molecular response for the prediction of outcomes in patients with advanced cancer, including the current state of science, its application in clinic, and next steps for the development of this predictive tool.
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晚期非小细胞肺癌中循环肿瘤DNA引导的疗法的总生存期。
影响因子：
82.9
作者：
Jee, Justin;Lebow, Emily S.;Yeh, Randy;Das, Jeeban P.;Namakydoust, Azadeh;Paik, Paul K.;Chaft, Jamie E.;Jayakumaran, Gowtham;Brannon, A. Rose;Benayed, Ryma;Zehir, Ahmet;Donoghue, Mark;Schultz, Nikolaus;Chakravarty, Debyani;Kundra, Ritika;Madupuri, Ramyasree;Murciano-Goroff, Yonina R.;Tu, Hai-Yan;Xu, Chong-Rui;Martinez, Andres;Wilhelm, Clare;Galle, Jesse;Daly, Bobby;Yu, Helena A.;Offin, Michael;Hellmann, Matthew D.;Lito, Piro;Arbour, Kathryn C.;Zauderer, Marjorie G.;Kris, Mark G.;Ng, Kenneth K.;Eng, Juliana;Preeshagul, Isabel;Lai, W. Victoria;Fiore, John J.;Iqbal, Afsheen;Molena, Daniela;Rocco, Gaetano;Park, Bernard J.;Lim, Lee P.;Li, Mark;Tong-Li, Candace;De Silva, Madhawa;Chan, David L.;Diakos, Connie, I;Itchins, Malinda;Clarke, Stephen;Pavlakis, Nick;Lee, Adrian;Rekhtman, Natasha;Chang, Jason;Travis, William D.;Riely, Gregory J.;Solit, David B.;Gonen, Mithat;Rusch, Valerie W.;Rimner, Andreas;Gomez, Daniel;Drilon, Alexander;Scher, Howard, I;Shah, Sohrab P.;Berger, Michael F.;Arcila, Maria E.;Ladanyi, Marc;Levine, Ross L.;Shen, Ronglai;Razavi, Pedram;Reis-Filho, Jorge S.;Jones, David R.;Rudin, Charles M.;Isbell, James M.;Li, Bob T.
通讯作者：
Li, Bob T.
影响因子：
4
作者：
通讯作者：
--
影响因子：
28.2
作者：
Hong DS;Morris VK;El Osta B;Sorokin AV;Janku F;Fu S;Overman MJ;Piha-Paul S;Subbiah V;Kee B;Tsimberidou AM;Fogelman D;Bellido J;Shureiqi I;Huang H;Atkins J;Tarcic G;Sommer N;Lanman R;Meric-Bernstam F;Kopetz S
通讯作者：
Kopetz S
影响因子：
22.7
作者：
Bratman, Scott V.;Yang, S. Y. Cindy;Pugh, Trevor J.
通讯作者：
Pugh, Trevor J.
影响因子：
50.5
作者：
Iwama, E.;Sakai, K.;Okamoto, I.
通讯作者：
Okamoto, I.