Opportunistic infections and immune deficiency in homosexual men.

Opportunistic infections and immune deficiency in homosexual men.
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男同性恋者的机会性感染和免疫缺陷。

DOI:
--
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发表时间:
1982
影响因子:
39.2
通讯作者:
I. Spigland
I. Spigland
中科院分区:
医学1区
文献类型:
--
作者:
D. Mildvan;U. Mathur;R. Enlow;P. L. Romain;R. Winchester;C. Colp;H. Singman;B. Adelsberg;I. Spigland

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在四名既往健康的同性恋男性中出现了一种机会性感染和获得性免疫缺陷综合征。发热、白细胞减少和迟发型超敏反应减弱,同时伴有不同程度的直肠炎、肛周溃疡和淋巴结病。病原体包括卡氏肺孢子虫、新型隐球菌、白色念珠菌、单纯疱疹病毒和巨细胞病毒。免疫缺陷的特征是辅助/诱导性T淋巴细胞亚群的功能及数量持续且严重的选择性下降,以及抑制性/细胞毒性T淋巴细胞亚群可能被激活。尽管进行了积极的抗感染治疗,仍有三名患者死亡。
A syndrome of opportunistic infections and acquired immune deficiency occurred among four previously healthy homosexual men. Fever, leukopenia, and diminished delayed hypersensitivity were accompanied by various degrees of proctitis, perianal ulcerations, and lymphadenopathy. The infectious agents included Pneumocystis carinii, Cryptococcus neoformans, Candida albicans, herpes simplex virus, and cytomegalovirus. The immune deficiency was characterized as a persistent and profound selective decrease in the function as well as number of T lymphocytes of the helper/inducer subset and a possible activation of the suppressor/cytotoxic subset. Three patients died despite aggressive anti-infective therapy.
巨细胞病毒单核细胞增多症中 T 淋巴细胞亚群的分析。
DOI: --
发表时间: 1981
期刊: Journal of immunology (Baltimore, Md. : 1950)
影响因子: --
作者:
Carney,WP;Rubin,RH;Hoffman,RA;Hansen,WP;Healey,K;Hirsch,MS
通讯作者: Hirsch,MS
与 T4 诱导 T 细胞功能丧失相关的免疫缺陷。
DOI: 10.1056/nejm198104023041403
发表时间: 1981
期刊: The New England journal of medicine
影响因子: --
作者:
Reinherz,EL;Geha,R;Wohl,ME;Morimoto,C;Rosen,FS;Schlossman,SF
通讯作者: Schlossman,SF
具核梭杆菌对人外周血 B 淋巴细胞的多克隆激活。
DOI: 10.1128/iai.40.3.1104-1111.1983
发表时间: 1983
影响因子: 3.1
作者:
Mangan,DF;Lopatin,DE
通讯作者: Lopatin,DE