Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.
Impact of sugar stereochemistry on natural killer T cell stimulation by bacterial glycolipids.
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DOI：
10.1039/c1ob06276j
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发表时间：
2011-10-26
影响因子：
3.2
通讯作者：
Savage PB
中科院分区：
文献类型：
--
作者：
Deng S;Mattner J;Zang Z;Bai L;Teyton L;Bendelac A;Savage PB
Natural killer T (NKT) cells recognize glycolipids produced by Sphingomonas bacteria, and these glycolipids contain C6-oxidized sugars, either glucuronic acid or galacturonic acid, linked to ceramides. Glycolipids with gluco stereochemistry are the most prevalent. Multiple studies have demonstrated that galactosylceramides are more potent stimulators of NKT cells than their glucose isomers. To determine if this stereoselectivity is retained in the context of the C6-oxidized sugars found in bacterial glycolipids, we prepared two sets of gluco and galacto-glycolipids oxidized at their C6 positions and compared their NKT stimulatory properties. In the context of carboxylic acid groups at C6, gluco stereochemistry gave the more potent responses. We also prepared bacterial glycolipids containing more complex ceramide groups to determine if these chains impact NKT cell responses.
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