Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases.
Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases.
复制标题
代谢组学：对其在非传染性疾病中作为疾病生物标志物发现工具的作用的范围综述
DOI：
10.3390/metabo11070418
复制
发表时间：
2021-06-25
期刊：
影响因子：
4.1
通讯作者：
Mukwevho E
中科院分区：
文献类型：
--
作者：
Aderemi AV;Ayeleso AO;Oyedapo OO;Mukwevho E
代谢组学是“组学”科学的一个分支，它利用几种分析工具来鉴定给定样品中的小分子（代谢物）。代谢组学的首要目标是定量和定性地评估这些代谢物的诊断，治疗和预后潜力。它在生活的各个方面的使用都有记录。我们还发表了一些论文，其中代谢组学方法用于研究代谢紊乱，如代谢综合征，糖尿病和肥胖症，但在动物模型中。由于每项研究的目标都是造福人类，因此本文旨在深入了解代谢组学在医学中的适用性维斯在疾病诊断和管理生物标志物发现中的作用。在这里，注意到在疾病状况的管理中具有经证实的诊断和治疗相关性的重要生物标志物，所述疾病状况例如阿尔茨海默病、痴呆、帕金森病、先天性代谢缺陷（IEM）、糖尿病视网膜病变和心血管疾病。本文还讨论了为什么大多数基于代谢组学的实验室发现不容易转化为临床的几个原因，以及如何解决这些问题。
Metabolomics is a branch of ‘omics’ sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-à-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer’s disease, dementia, Parkinson’s disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward.
登录
查看更多内容
DOI：
10.1016/j.bbrc.2018.03.117
发表时间：
2018-05-05
影响因子：
3.1
作者：
Carlson AK;Rawle RA;Adams E;Greenwood MC;Bothner B;June RK
通讯作者：
June RK
代谢组学研究中的NMR技术：有关利用示例的快速概述。
影响因子：
1
作者：
Kruk J;Doskocz M;Jodłowska E;Zacharzewska A;Łakomiec J;Czaja K;Kujawski J
通讯作者：
Kujawski J
影响因子：
4.2
作者：
Coene, Karlien L. M.;Kluijtmans, Leo A. J.;Wevers, Ron A.
通讯作者：
Wevers, Ron A.
影响因子：
4.4
作者：
Haines, Nathan R.;Manoharan, Niranjan;Reisz, Julie A.
通讯作者：
Reisz, Julie A.
DOI：
10.1016/j.jpba.2021.113971
发表时间：
2021-02-24
影响因子：
3.4
作者：
Dudka, Ilona;Chachaj, Angelika;Szuba, Andrzej
通讯作者：
Szuba, Andrzej