Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
复制标题
DOI：
10.1038/ng.444
复制
发表时间：
2009-10
期刊：
影响因子：
30.8
通讯作者：
Chanock, Stephen J.
中科院分区：
文献类型：
--
作者：
Yeager, Meredith;Chatterjee, Nilanjan;Ciampa, Julia;Jacobs, Kevin B.;Gonzalez-Bosquet, Jesus;Hayes, Richard B.;Kraft, Peter;Wacholder, Sholom;Orr, Nick;Berndt, Sonja;Yu, Kai;Hutchinson, Amy;Wang, Zhaoming;Amundadottir, Laufey;Feigelson, Heather Spencer;Thun, Michael J.;Diver, W. Ryan;Albanes, Demetrius;Virtamo, Jarmo;Weinstein, Stephanie;Schumacher, Fredrick R.;Cancel-Tassin, Geraldine;Cussenot, Olivier;Valeri, Antoine;Andriole, Gerald L.;Crawford, E. David;Haiman, Christopher A.;Henderson, Brian;Kolonel, Laurence;Le Marchand, Loic;Siddiq, Afshan;Riboli, Elio;Key, Timothy J.;Kaaks, Rudolf;Isaacs, William;Isaacs, Sarah;Wiley, Kathleen E.;Gronberg, Henrik;Wiklund, Fredrik;Stattin, Par;Xu, Jianfeng;Zheng, S. Lilly;Sun, Jielin;Vatten, Lars J.;Hveem, Kristian;Kumle, Merethe;Tucker, Margaret;Gerhard, Daniela S.;Hoover, Robert N.;Fraumeni, Joseph F., Jr.;Hunter, David J.;Thomas, Gilles;Chanock, Stephen J.
我们在癌症易感性遗传标记（CGEMS）计划中报告了一项10,286例病例和9,135例对照的全基因组关联研究，确定了染色体8q24与前列腺癌风险的新关联（rs620861, p=1.3×10-10，杂合子OR = 1.17, 95% CI 1.10 - 1.24；纯合子OR = 1.33; 95% CI 1.21 - 1.45）。这在8q24第4区定义了一个新的前列腺位点，以前与乳腺癌相关。
We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry, in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative, identifying a new association with prostate cancer risk on chromosome 8q24 (rs620861, p=1.3×10-10, heterozygote OR = 1.17, 95% CI 1.10 – 1.24; homozygote OR = 1.33; 95% CI 1.21 – 1.45). This defines a new prostate locus on 8q24, Region 4, previously associated with breast cancer.
登录
查看更多内容
影响因子：
30.8
作者：
Kiemeney LA;Thorlacius S;Sulem P;Geller F;Aben KK;Stacey SN;Gudmundsson J;Jakobsdottir M;Bergthorsson JT;Sigurdsson A;Blondal T;Witjes JA;Vermeulen SH;Hulsbergen-van de Kaa CA;Swinkels DW;Ploeg M;Cornel EB;Vergunst H;Thorgeirsson TE;Gudbjartsson D;Gudjonsson SA;Thorleifsson G;Kristinsson KT;Mouy M;Snorradottir S;Placidi D;Campagna M;Arici C;Koppova K;Gurzau E;Rudnai P;Kellen E;Polidoro S;Guarrera S;Sacerdote C;Sanchez M;Saez B;Valdivia G;Ryk C;de Verdier P;Lindblom A;Golka K;Bishop DT;Knowles MA;Nikulasson S;Petursdottir V;Jonsson E;Geirsson G;Kristjansson B;Mayordomo JI;Steineck G;Porru S;Buntinx F;Zeegers MP;Fletcher T;Kumar R;Matullo G;Vineis P;Kiltie AE;Gulcher JR;Thorsteinsdottir U;Kong A;Rafnar T;Stefansson K
通讯作者：
Stefansson K
影响因子：
30.8
作者：
Zanke, Brent W.;Greenwood, Celia M. T.;Dunlop, Malcolm G.
通讯作者：
Dunlop, Malcolm G.
影响因子：
30.8
作者：
Pomerantz, Mark M.;Ahmadiyeh, Nasim;Jia, Li;Herman, Paula;Verzi, Michael P.;Doddapaneni, Harshavardhan;Beckwith, Christine A.;Chan, Jennifer A.;Hills, Adam;Davis, Matt;Yao, Keluo;Kehoe, Sarah M.;Lenz, Heinz-Josef;Haiman, Christopher A.;Yan, Chunli;Henderson, Brian E.;Frenkel, Baruch;Barretina, Jordi;Bass, Adam;Tabernero, Josep;Baselga, Jose;Regan, Meredith M.;Manak, J. Robert;Shivdasani, Ramesh;Coetzee, Gerhard A.;Freedman, Matthew L.
通讯作者：
Freedman, Matthew L.
影响因子：
30.8
作者：
Haiman, Christopher A.;Patterson, Nick;Reich, David
通讯作者：
Reich, David
影响因子：
10.3
作者：
Ghoussaini, Maya;Song, Honglin;Dunning, Alison M.
通讯作者：
Dunning, Alison M.