Four-year follow-up of surgical versus non-surgical therapy for chronic low back pain.

Four-year follow-up of surgical versus non-surgical therapy for chronic low back pain.
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DOI:
10.1136/ard.2009.108902
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发表时间:
2010-09
影响因子:
27.4
通讯作者:
Reikerås O
Reikerås O
中科院分区:
医学1区
文献类型:
--
作者:
Brox JI;Nygaard ØP;Holm I;Keller A;Ingebrigtsen T;Reikerås O

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比较手术与非手术治疗慢性腰痛患者的远期疗效。两项合并的随机临床试验比较了124例椎间盘退变患者的经椎弓根融合术与认知干预和运动,这些患者在椎间盘突出手术后或未进行手术后至少有1年的症状。主要结局指标为Oswestry残疾指数。在4年时,14名(24%)随机分配到认知干预和锻炼组的患者也接受了手术。15例(23%)患者接受了再次手术。主要结局的平均治疗效果为1.1;根据意向治疗分析,95% CI为−5.9至8.2,CI为−1.6;在治疗组分析中,95% CI为−8.9 ~ 5.6。回到工作岗位上没有什么不同。与认知干预和运动相比,经椎弓根融合术后的长期改善并不更好。
To compare the long-term effectiveness of surgical and non-surgical treatment in patients with chronic low back pain. Two merged randomised clinical trials compared instrumented transpedicular fusion with cognitive intervention and exercises in 124 patients with disc degeneration and at least 1 year of symptoms after or without previous surgery for disc herniation. The main outcome measure was the Oswestry disability index. At 4 years 14 (24%) patients randomly assigned to cognitive intervention and exercises had also undergone surgery. 15 (23%) patients assigned fusion had undergone re-surgery. The mean treatment effect for the primary outcome was 1.1; 95% CI −5.9 to 8.2, according to the intention-to-treat analysis and −1.6; 95% CI −8.9 to 5.6 in the as-treated analysis. There was no difference in return to work. Long-term improvement was not better after instrumented transpedicular fusion compared with cognitive intervention and exercises.
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