Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea.
Periodontitis is associated with rheumatoid arthritis: a study with longstanding rheumatoid arthritis patients in Korea.
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牙周炎与类风湿关节炎有关：韩国长期存在类风湿关节炎患者的研究。
DOI：
10.3904/kjim.2015.202
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发表时间：
2016-09
期刊：
影响因子：
--
通讯作者：
Song YW
中科院分区：
文献类型：
--
作者：
Choi IA;Kim JH;Kim YM;Lee JY;Kim KH;Lee EY;Lee EB;Lee YM;Song YW
为探讨牙周炎的严重程度与类风湿关节炎(RA)临床表现之间的关系，进行了一项横断面研究。264例类风湿性关节炎患者和88例年龄、性别匹配的对照组进行了牙科检查。此外，还评估了RA患者的临床表现，包括疾病活动性和抗瓜氨酸蛋白抗体。RA患者中重度牙周炎的患病率高于对照组(63.6%比34.1%，p<；0.001)。在牙周炎症标志物中，探诊出血与疾病活动性评分28(r=0.128，p=0.041)、RA病程(r=0.211，p=0.001)、血沉(血沉；r=0.141，p=0.023)、抗环瓜氨酸肽抗体(r=0.183，p=0.009)和抗瓜氨酸烯醇化α-1抗体(r=0.143，p=0.025)相关。牙龈指数与RA病程(r=0.262，p<；0.001)、血沉(r=0.162，p=0.009)、抗环瓜氨酸肽抗体(r=0.203，p=0.004)和抗瓜氨酸烯醇化α-1抗体(r=0.225，p<；0.001)相关。具有人类白细胞抗原-DRB1共有表位的RA患者牙周结构损伤以探诊袋深度和临床附着水平为代表，明显低于无共有表位的RA患者(p=0.005和p=0.006)。与对照组相比，类风湿性关节炎患者中重度牙周炎的患病率增加。牙周炎与RA病程、血沉和抗瓜氨酸蛋白抗体相关。HLA-DRB1共有表位的RA患者牙周结构损害较轻。
A cross-sectional study was undertaken to investigate the association between severity of periodontitis and clinical manifestation of rheumatoid arthritis (RA). Two hundred sixty-four RA patients and 88 age- and sex-matched controls underwent dental exam. Additionally, clinical manifestations including disease activity and anti-citrullinated protein antibodies were evaluated in RA patients. The prevalence of moderate or severe periodontitis was higher in RA patients compared to controls (63.6% vs 34.1%, p < 0.001). In markers of periodontal inflammation, bleeding on probing was correlated with disease activity score 28 (r = 0.128, p = 0.041), RA disease duration (r = 0.211, p = 0.001), erythrocyte sedimentation rate (ESR; r = 0.141, p = 0.023), anti-cyclic citrullinated peptide antibody (r = 0.183, p = 0.009), and anti-citrullinated α-enolase peptide-1 antibody (r = 0.143, p = 0.025). Gingival index was correlated with RA duration (r = 0.262, p < 0.001), ESR (r = 0.162, p = 0.009), anti-cyclic citrullinated peptide antibody (r = 0.203, p = 0.004) and anti-citrullinated α-enolase peptide-1 antibody (r = 0.225, p < 0.001). Periodontal structural damage represented by probing pocket depth and clinical attachment level were less in RA patients with human leukocyte antigen (HLA)-DRB1 shared epitope compared than those without shared epitope (p = 0.005 and p =0.006, respectively). The prevalence of moderate or severe periodontitis was increased in RA patients compared to controls. Periodontal inflammation was correlated with RA disease duration, ESR, and anti-citrullinated protein antibodies. Periodontal structural damage was less in RA patients with HLA-DRB1 shared epitope.
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影响因子：
4.9
作者：
Arvikar SL;Collier DS;Fisher MC;Unizony S;Cohen GL;McHugh G;Kawai T;Strle K;Steere AC
通讯作者：
Steere AC
影响因子：
4.9
作者：
Marchesan JT;Gerow EA;Schaff R;Taut AD;Shin SY;Sugai J;Brand D;Burberry A;Jorns J;Lundy SK;Nuñez G;Fox DA;Giannobile WV
通讯作者：
Giannobile WV
影响因子：
4.9
作者：
Vander Cruyssen B;Van Looy S;Wyns B;Westhovens R;Durez P;Van den Bosch F;Veys EM;Mielants H;De Clerck L;Peretz A;Malaise M;Verbruggen L;Vastesaeger N;Geldhof A;Boullart L;De Keyser F
通讯作者：
De Keyser F
影响因子：
2
作者：
LOE, HARALD;SILNESS, JOHN
通讯作者：
SILNESS, JOHN
影响因子：
--
作者：
Lundberg, Karin;Kinloch, Andrew;Venables, Patrick J.
通讯作者：
Venables, Patrick J.