Pulmonary responses in current smokers and ex-smokers following a two hour exposure at rest to clean air and fine ambient air particles.
Pulmonary responses in current smokers and ex-smokers following a two hour exposure at rest to clean air and fine ambient air particles.
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DOI：
10.1186/1743-8977-10-58
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发表时间：
2013-11-18
影响因子：
10
通讯作者：
Devlin RB
中科院分区：
文献类型：
--
作者：
Hazucha MJ;Bromberg PA;Lay JC;Bennett W;Zeman K;Alexis NE;Kehrl H;Rappold AG;Cascio WE;Devlin RB
吸烟者对周围PM的易感性增加可能会促进COPD的发展并加速已经存在的疾病。描述既往吸烟者和终生吸烟者受控室暴露于MMAD ≤ 2.5 μ m的浓缩环境细颗粒物（CAFP）的急性和亚急性肺功能反应和炎症效应。11例年龄在35-74岁之间的受试者来实验室5次; 1个培训日和2个暴露日至少间隔3周，每个暴露日22小时后进行暴露后访视。双盲和平衡暴露于“清洁空气”（平均1.5 ± 0.6 μg/m3）或CAFP（平均108.7 ± 24.8 μg/m3）持续2小时，受试者处于休息状态。在暴露后3小时，受试者的DTPA清除半衰期相对于“清洁空气”显著增加6.3分钟/100 μg/m3的CAFP。在暴露后22小时，与“清洁空气”相比，每100 μg/m3的CAFP，FEV 1显著降低4.3%，DLCO显著降低11.1%。在3小时和22小时，HDL胆固醇水平分别显著降低4.5%和4.1%。在任何条件下，其他血液化学和肺损伤标志物、炎症和促凝血活性均在正常值范围内。结果表明，吸烟者和戒烟者急性2 h静息暴露于环境细颗粒物可能会短暂影响肺功能（肺功能测定和DLCO），并增加DTPA清除半衰期。除了暴露后HDL降低外，在暴露条件下，肺部炎症、血栓前活动和肺损伤的其他标志物均未受到显著影响。
Increased susceptibility of smokers to ambient PM may potentially promote development of COPD and accelerate already present disease. To characterize the acute and subacute lung function response and inflammatory effects of controlled chamber exposure to concentrated ambient fine particles (CAFP) with MMAD ≤ 2.5 microns in ex-smokers and lifetime smokers. Eleven subjects, aged 35–74 years, came to the laboratory 5 times; a training day and two exposure days separated by at least 3 weeks, each with a post-exposure visit 22 h later. Double-blind and counterbalanced exposures to “clean air” (mean 1.5 ± 0.6 μg/m3) or CAFP (mean 108.7 ± 24.8 μg/m3 ) lasted 2 h with subjects at rest. At 3 h post-exposure subjects’ DTPA clearance half-time significantly increased by 6.3 min per 100 μg/m3 of CAFP relative to “clean air”. At 22 h post-exposure they showed significant reduction of 4.3% per 100 μg/m3 in FEV1 and a significant DLCO decrease by 11.1% per 100 μg/m3 of CAFP relative to “clean air”. At both 3 h and 22 h the HDL cholesterol level significantly decreased by 4.5% and 4.1%, respectively. Other blood chemistries and markers of lung injury, inflammation and procoagulant activity were within the normal range of values at any condition. The results suggest that an acute 2 h resting exposure of smokers and ex-smokers to fine ambient particulate matter may transiently affect pulmonary function (spirometry and DLCO) and increase DTPA clearance half-time. Except for a post exposure decrease in HDL no other markers of pulmonary inflammation, prothrombotic activity and lung injury were significantly affected under the conditions of exposure.
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影响因子：
37.8
作者：
Pope, CA;Burnett, RT;Godleski, JJ
通讯作者：
Godleski, JJ
DOI：
10.1164/rccm.200811-1757st
发表时间：
2010-09-01
影响因子：
24.7
作者：
Eisner, Mark D.;Anthonisen, Nicholas;Balmes, John R.
通讯作者：
Balmes, John R.
影响因子：
2.1
作者：
Pietropaoli, AP;Frampton, MW;Utell, MJ
通讯作者：
Utell, MJ
DOI：
10.1164/rccm.200406-710st
发表时间：
2005-04-15
影响因子：
24.7
作者：
American Thoracic Society;European Respiratory Society
通讯作者：
European Respiratory Society
影响因子：
3.3
作者：
DUSSER, DJ;MINTY, BD;HUCHON, GJ
通讯作者：
HUCHON, GJ